Numb NUMB, endocytic adaptor protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Numbprovided by RGD
Official Full Name: NUMB, endocytic adaptor proteinprovided by RGD
Primary source: RGD:620107
See related: EnsemblRapid:ENSRNOG00000009653 AllianceGenome:RGD:620107
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable alpha-catenin binding activity; beta-catenin binding activity; and cadherin binding activity. Involved in positive regulation of dendrite morphogenesis; regulation of neuron differentiation; and regulation of postsynapse assembly. Located in apical part of cell and dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human NUMB (NUMB endocytic adaptor protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 238.5), Kidney (RPKM 186.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (109162499..109284527, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (103431400..103553422, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (107279917..107325345, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NUMB attenuates posttraumatic osteoarthritis by inhibiting BTRC and inactivating the NF-kappaB pathway.
Title: NUMB attenuates posttraumatic osteoarthritis by inhibiting BTRC and inactivating the NF-κB pathway.
The PTB and PRR domains of numb regulate neurite outgrowth by influencing voltage-gated calcium channel expression and kinetics.
Title: The PTB and PRR domains of numb regulate neurite outgrowth by influencing voltage-gated calcium channel expression and kinetics.
BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction.
Title: BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction.
[Overexpression of Numb gene can inhibit the progression of biliary liver fibrosis in adult liver].
Title: [Overexpression of Numb gene can inhibit the progression of biliary liver fibrosis in adult liver].
Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis.
Title: Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis.
activating Nrf2 antioxidant pathway suppresses Epithelial mesenchymal transition during pulmonary fibrosis via inhibiting the abnormal expression of Numb.
Title: Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis.
The pattern of Notch2, Numb, and Casp8 gene expression in prefrontal cortex, hippocampus, and cerebellum of the rat brain during formation of spatial memory has been reported.
Title: Pattern of Notch2, Numb, and Cas8 Gene Expression in Relevant Structures of the Rat Brain during Formation of Spatial Memory.
Numb is a pivotal adaptor protein that mediates the subcellular localization of EAAT3 through binding the YxNxxF (where x stands for any amino acid) motif.
Title: Numb directs the subcellular localization of EAAT3 through binding the YxNxxF motif.
This work identifies Numb as an important player in renal fibrosis, by regulating epithelial-to-mesenchymal transition (EMT) process including E-cadherin adhesion dissolution, actin reorganization, and migration enhancement in NRK52E cells.
Title: Numb induces e-cadherin adhesion dissolution, cytoskeleton reorganization, and migration in tubular epithelial cells contributing to renal fibrosis.
Numb expression is upregulated during cerebral ischemia and promotes apoptosis.
Title: Numb/Notch signaling plays an important role in cerebral ischemia-induced apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137440 (e-PCR)
- UniSTS:219528

AI407449 (e-PCR)
- UniSTS:261848

BE120274 (e-PCR)
- UniSTS:247284

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-catenin binding	IEA Inferred from Electronic Annotation more info
enables alpha-catenin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in lateral ventricle development	IEA Inferred from Electronic Annotation more info
involved_in lateral ventricle development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neuroblast division in subventricular zone	IEA Inferred from Electronic Annotation more info
involved_in neuroblast division in subventricular zone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
NOT located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: protein numb homolog

Names: numb gene homolog; numb homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411953.1 → NP_001398882.1 protein numb homolog isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

F1LRS4, Q2LC85
NM_001411954.1 → NP_001398883.1 protein numb homolog isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

Q2LC86

Related

ENSRNOP00000110385.1, ENSRNOT00000129974.1
NM_001411955.1 → NP_001398884.1 protein numb homolog isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

Related

ENSRNOP00000042586.6, ENSRNOT00000042594.7
NM_001411956.1 → NP_001398885.1 protein numb homolog isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

F1LNZ2, Q2LC87

Related

ENSRNOP00000048410.5, ENSRNOT00000049481.7
NM_133287.2 → NP_579821.2 protein numb homolog isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

Q2LC86

Related

ENSRNOP00000111448.1, ENSRNOT00000150573.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

109162499..109284527 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111838.2 → XP_038967766.1 protein numb homolog isoform X4

UniProtKB/TrEMBL

Q2LC86, Q3MUI1

Conserved Domains (2) summary

cd01268
Location:23 → 157

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:248 → 326

NumbF; NUMB domain
XM_039111829.2 → XP_038967757.1 protein numb homolog isoform X2

UniProtKB/Swiss-Prot

B2GVA9, F1MAI8, Q2LC84

Conserved Domains (2) summary

cd01268
Location:23 → 168

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:259 → 337

NumbF; NUMB domain
XM_063261581.1 → XP_063117651.1 protein numb homolog isoform X3
XM_063261578.1 → XP_063117648.1 protein numb homolog isoform X1
XM_063261580.1 → XP_063117650.1 protein numb homolog isoform X2
XM_039111833.2 → XP_038967761.1 protein numb homolog isoform X2

UniProtKB/Swiss-Prot

B2GVA9, F1MAI8, Q2LC84

Conserved Domains (2) summary

cd01268
Location:23 → 168

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:259 → 337

NumbF; NUMB domain
XM_039111832.2 → XP_038967760.1 protein numb homolog isoform X2

UniProtKB/Swiss-Prot

B2GVA9, F1MAI8, Q2LC84

Conserved Domains (2) summary

cd01268
Location:23 → 168

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:259 → 337

NumbF; NUMB domain
XM_039111834.1 → XP_038967762.1 protein numb homolog isoform X2

UniProtKB/Swiss-Prot

B2GVA9, F1MAI8, Q2LC84

Conserved Domains (2) summary

cd01268
Location:23 → 168

PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain

pfam06311
Location:259 → 337

NumbF; NUMB domain
XM_063261579.1 → XP_063117649.1 protein numb homolog isoform X1