Acvr1b activin A receptor type 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acvr1bprovided by RGD
Official Full Name: activin A receptor type 1Bprovided by RGD
Primary source: RGD:735207
See related: EnsemblRapid:ENSRNOG00000006934 AllianceGenome:RGD:735207
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Skr2
Summary: Predicted to enable several functions, including ATP binding activity; I-SMAD binding activity; and activin binding activity. Predicted to contribute to activin receptor activity and growth factor binding activity. Involved in several processes, including activin receptor signaling pathway; cardiac fibroblast cell development; and positive regulation of biosynthetic process. Predicted to be located in cell surface and cytosol. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; malignant mesothelioma; pancreatic cancer; and stomach cancer. Orthologous to human ACVR1B (activin A receptor type 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 81.1), Brain (RPKM 55.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (134164987..134208389)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (132286266..132329679)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (142817174..142858365)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lower ALK4 mRNA expression is noted in the brown adipose tissue of exercising diabetic rats compared with sedentary diabetic rats.
Title: Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise.
In a rat model of HF, we demonstrated a concerted induction of the gene expression of activin betaA and activin receptors IA, IB, IIA, and IIB after myocardial infarction.
Title: Elevated levels of activin A in heart failure: potential role in myocardial remodeling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142902 (e-PCR)
- UniSTS:232149

Acvr1b (e-PCR), detects polymorphism
- UniSTS:233951

RH139325 (e-PCR)
- UniSTS:221411

UniSTS:496629 (e-PCR)
- UniSTS:496629

Acvr1b (e-PCR), detects polymorphism
- UniSTS:496629

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables BMP receptor activity	IEA Inferred from Electronic Annotation more info
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info
enables I-SMAD binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin binding	IEA Inferred from Electronic Annotation more info
contributes_to activin binding	ISO Inferred from Sequence Orthology more info
enables activin binding	ISO Inferred from Sequence Orthology more info
contributes_to activin receptor activity	ISO Inferred from Sequence Orthology more info
enables activin receptor activity	ISO Inferred from Sequence Orthology more info
enables activin receptor activity, type I	IBA Inferred from Biological aspect of Ancestor more info
enables activin receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables activin receptor activity, type I	ISO Inferred from Sequence Orthology more info
enables activin receptor activity, type I	TAS Traceable Author Statement more info	PubMed
enables activin receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
contributes_to growth factor binding	ISO Inferred from Sequence Orthology more info
enables inhibin binding	IEA Inferred from Electronic Annotation more info
enables inhibin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type III	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in activin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cardiac fibroblast cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in development of primary female sexual characteristics	IEP Inferred from Expression Pattern more info	PubMed
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hair follicle development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nodal signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nodal signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of trophoblast cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of activin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of activin receptor complex	IEA Inferred from Electronic Annotation more info
part_of activin receptor complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: activin receptor type-1B

Names: ACTR-IB; ALK-4; Serine/threonine-protein kinase receptor R2; activin A receptor, type IB; activin receptor type IB; activin receptor-like kinase 4

NP_954700.1

EC 2.7.11.30

XP_006242377.1

EC 2.7.11.30

XP_038934506.1

EC 2.7.11.30

XP_038934507.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199230.2 → NP_954700.1 activin receptor type-1B precursor

See identical proteins and their annotated locations for NP_954700.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P80202

UniProtKB/TrEMBL

A0A8I6AKG7

Related

ENSRNOP00000009345.6, ENSRNOT00000009345.9

Conserved Domains (3) summary

smart00467
Location:177 → 207

GS; GS motif

cd14143
Location:211 → 498

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:38 → 104

Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

134164987..134208389

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078579.2 → XP_038934507.1 activin receptor type-1B isoform X1

UniProtKB/TrEMBL

A6KCN3

Conserved Domains (2) summary

smart00467
Location:125 → 155

GS; GS motif

cd14143
Location:159 → 446

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
XM_006242315.5 → XP_006242377.1 activin receptor type-1B isoform X1

See identical proteins and their annotated locations for XP_006242377.1

UniProtKB/TrEMBL

A6KCN3

Conserved Domains (2) summary

smart00467
Location:125 → 155

GS; GS motif

cd14143
Location:159 → 446

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
XM_039078578.2 → XP_038934506.1 activin receptor type-1B isoform X1

UniProtKB/TrEMBL

A6KCN3

Conserved Domains (2) summary

smart00467
Location:125 → 155

GS; GS motif

cd14143
Location:159 → 446

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors