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Incenp inner centromere protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 293733, updated on 4-Jan-2025

Summary

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Official Symbol
Incenpprovided by RGD
Official Full Name
inner centromere proteinprovided by RGD
Primary source
RGD:1305292
See related
EnsemblRapid:ENSRNOG00000032929 AllianceGenome:RGD:1305292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable molecular function activator activity. Predicted to be involved in meiotic spindle midzone assembly; metaphase chromosome alignment; and mitotic cytokinesis. Predicted to be located in several cellular components, including chromocenter; nuclear lumen; and pericentric heterochromatin. Predicted to be part of chromosome passenger complex. Predicted to be active in several cellular components, including kinetochore; meiotic spindle midzone; and midbody. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 127.6), Spleen (RPKM 95.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Incenp in Genome Data Viewer
Location:
1q43
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215945558..216017247, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206520655..206550575, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225923448..225953384, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene secretoglobin, family 1D, member 2, pseudogene 1 Neighboring gene secretoglobin, family 2A, member 1 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1, pseudogene 1 Neighboring gene ferritin heavy chain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. Ainsztein AM, et al. J Cell Biol, 1998 Dec 28. PMID 9864353, Free PMC Article
  2. Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. Vader G, et al. EMBO Rep, 2006 Jan. PMID 16239925, Free PMC Article
  3. Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Qi W, et al. Mol Biol Cell, 2006 Aug. PMID 16760428, Free PMC Article
  4. Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis. Parra MT, et al. J Cell Sci, 2003 Mar 15. PMID 12584241
  5. Sequential assembly of centromeric proteins in male mouse meiosis. Parra MT, et al. PLoS Genet, 2009 Mar. PMID 19283064, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in central element ISO
Inferred from Sequence Orthology
more info
  
located_in chromocenter ISO
Inferred from Sequence Orthology
more info
  
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromosome passenger complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in lateral element ISO
Inferred from Sequence Orthology
more info
  
is_active_in meiotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in synaptonemal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inner centromere protein
Names
inner centromere protein antigens 135/155kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106335.1 → NP_001099805.1  inner centromere protein

    See identical proteins and their annotated locations for NP_001099805.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A6I000, D3ZXY1
    Related
    ENSRNOP00000047950.4, ENSRNOT00000043387.5
    Conserved Domains (4) summary
    pfam03941
    Location:815 → 866
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:6 → 41
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cd16269
    Location:601 → 612
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:528 → 632
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    215945558..216017247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286935.1 → XP_063143005.1  inner centromere protein isoform X3

  2. XM_063286932.1 → XP_063143002.1  inner centromere protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZ56

  3. XM_006231025.3 → XP_006231087.1  inner centromere protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZP23, A0A8I5ZZ56
    Related
    ENSRNOP00000080126.1, ENSRNOT00000096008.2
    Conserved Domains (4) summary
    pfam03941
    Location:839 → 890
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:30 → 65
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cd16269
    Location:625 → 636
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:552 → 656
    GBP_C; Guanylate-binding protein, C-terminal domain

  4. XM_063286938.1 → XP_063143008.1  inner centromere protein isoform X3

    UniProtKB/TrEMBL
    A6I000, D3ZXY1

  5. XM_063286940.1 → XP_063143010.1  inner centromere protein isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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