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Trmt112 tRNA methyltransferase activator subunit 11-2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293700, updated on 27-Nov-2024

Summary

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Official Symbol
Trmt112provided by RGD
Official Full Name
tRNA methyltransferase activator subunit 11-2provided by RGD
Primary source
RGD:1309710
See related
EnsemblRapid:ENSRNOG00000073020 AllianceGenome:RGD:1309710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309710
Summary
Predicted to enable protein heterodimerization activity; protein methyltransferase activity; and tRNA methyltransferase activator activity. Predicted to be involved in RNA metabolic process; peptidyl-glutamine methylation; and positive regulation of rRNA processing. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of tRNA (m2G10) methyltransferase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 438.4), Adrenal (RPKM 417.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trmt112 in Genome Data Viewer
Location:
1q43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213532507..213533360)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204103298..204104151)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222167927..222168780)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483961 Neighboring gene ATP synthase membrane subunit c locus 1 like 1 Neighboring gene peroxiredoxin 5 Neighboring gene estrogen related receptor, alpha Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene uncharacterized LOC134483962 Neighboring gene potassium two pore domain channel subfamily K member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Metzger E, et al. Nat Struct Mol Biol, 2019 May. PMID 31061526
  2. Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates. Kusevic D, et al. J Biol Chem, 2016 Mar 18. PMID 26797129, Free PMC Article
  3. The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. van Tran N, et al. Nucleic Acids Res, 2019 Sep 5. PMID 31328227, Free PMC Article
  4. The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. Zorbas C, et al. Mol Biol Cell, 2015 Jun 1. PMID 25851604, Free PMC Article
  5. HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1. Figaro S, et al. FEBS Lett, 2008 Jul 9. PMID 18539146

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA methyltransferase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-glutamine methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA (guanine-N7)-methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
multifunctional methyltransferase subunit TRM112-like protein
Names
tRNA methyltransferase 112 homolog
tRNA methyltransferase subunit 11-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106330.2 → NP_001099800.1  multifunctional methyltransferase subunit TRM112-like protein

    See identical proteins and their annotated locations for NP_001099800.1

    Status: VALIDATED

    Source sequence(s)
    BP485075, DV720088
    UniProtKB/TrEMBL
    A6HZJ2, B2RYS9, B5DEM8
    Related
    ENSRNOP00000105490.1, ENSRNOT00000155932.1
    Conserved Domains (1) summary
    cd21089
    Location:2 → 118
    Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213532507..213533360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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