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Cars1 cysteinyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293638, updated on 2-Nov-2024

Summary

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Official Symbol
Cars1provided by RGD
Official Full Name
cysteinyl-tRNA synthetase 1provided by RGD
Primary source
RGD:1310747
See related
EnsemblRapid:ENSRNOG00000020651 AllianceGenome:RGD:1310747
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cars
Summary
Predicted to enable several functions, including ATP binding activity; cysteine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 143.9), Brain (RPKM 100.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cars1 in Genome Data Viewer
Location:
1q42
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208183092..208225425, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198753689..198796016, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216759367..216801652, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology-like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene small nucleolar RNA, H/ACA box 54 Neighboring gene uncharacterized LOC134483952 Neighboring gene transfer RNA valine (anticodon AAC) 16 Neighboring gene tumor necrosis factor receptor superfamily, member 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Kinetic quality control of anticodon recognition by a eukaryotic aminoacyl-tRNA synthetase. Liu C, et al. J Mol Biol, 2007 Apr 6. PMID 17303165, Free PMC Article
  2. Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase. Davidson E, et al. Biol Chem, 2001 Mar. PMID 11347887
  3. An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing. Kim JE, et al. Nucleic Acids Res, 2000 Aug 1. PMID 10908348, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cysteinyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cysteinyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cysteine--tRNA ligase, cytoplasmic
Names
cysteinyl-tRNA synthetase, cytoplasmic
NP_001099789.1
XP_006230775.1
XP_038964041.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106319.1 → NP_001099789.1  cysteine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_001099789.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A0A8I6AVG0, A6HYC5, G3V9K0
    Related
    ENSRNOP00000050342.2, ENSRNOT00000050721.5
    Conserved Domains (2) summary
    cd00672
    Location:30 → 445
    CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
    PTZ00399
    Location:1 → 745
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    208183092..208225425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230713.5 → XP_006230775.1  cysteine--tRNA ligase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_006230775.1

    UniProtKB/TrEMBL
    A0A8I5Y9V4, A0A8I6AVG0, A6HYC6
    Related
    ENSRNOP00000078006.1, ENSRNOT00000097888.2
    Conserved Domains (3) summary
    cd00672
    Location:113 → 528
    CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
    cd10310
    Location:4 → 76
    GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
    PTZ00399
    Location:91 → 828
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  2. XM_039108113.2 → XP_038964041.1  cysteine--tRNA ligase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    A0A8I6AVG0
    Conserved Domains (1) summary
    PTZ00399
    Location:1 → 681
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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