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Ino80e INO80 complex subunit E [ Rattus norvegicus (Norway rat) ]

Gene ID: 293494, updated on 4-Jan-2025

Summary

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Official Symbol
Ino80eprovided by RGD
Official Full Name
INO80 complex subunit Eprovided by RGD
Primary source
RGD:1359572
See related
EnsemblRapid:ENSRNOG00000019960 AllianceGenome:RGD:1359572
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc95
Summary
Predicted to be involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Ino80 complex. Orthologous to human INO80E (INO80 complex subunit E). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 97.2), Kidney (RPKM 90.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ino80e in Genome Data Viewer
Location:
1q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190891315..190902902, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181461406..181472059, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198287489..198298076, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TLC domain containing 3B Neighboring gene uncharacterized LOC134483857 Neighboring gene similar to human chromosome 16 open reading frame 92 Neighboring gene double C2 domain alpha Neighboring gene HIRA interacting protein 3 Neighboring gene TAO kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Chen L, et al. J Biol Chem, 2011 Apr 1. PMID 21303910, Free PMC Article
  2. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
INO80 complex subunit E
Names
coiled-coil domain containing 95
coiled-coil domain-containing protein 95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013900.1 → NP_001013922.1  INO80 complex subunit E

    See identical proteins and their annotated locations for NP_001013922.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079045
    UniProtKB/Swiss-Prot
    Q6AYH2
    UniProtKB/TrEMBL
    A0A8I6G9J0, A6I9G3
    Related
    ENSRNOP00000027034.5, ENSRNOT00000027033.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    190891315..190902902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286191.1 → XP_063142261.1  INO80 complex subunit E isoform X9

  2. XM_063286198.1 → XP_063142268.1  INO80 complex subunit E isoform X11

    UniProtKB/TrEMBL
    A6I9G9

  3. XM_063286185.1 → XP_063142255.1  INO80 complex subunit E isoform X8

  4. XM_063286151.1 → XP_063142221.1  INO80 complex subunit E isoform X1

    UniProtKB/Swiss-Prot
    Q6AYH2
    UniProtKB/TrEMBL
    A0A8I6G9J0, A6I9G3

  5. XM_063286152.1 → XP_063142222.1  INO80 complex subunit E isoform X1

    UniProtKB/Swiss-Prot
    Q6AYH2
    UniProtKB/TrEMBL
    A0A8I6G9J0, A6I9G3

  6. XM_063286175.1 → XP_063142245.1  INO80 complex subunit E isoform X6

    UniProtKB/TrEMBL
    A0A8I6G9J0

  7. XM_063286168.1 → XP_063142238.1  INO80 complex subunit E isoform X4

    UniProtKB/TrEMBL
    A0A8I6G9J0

  8. XM_006230243.4 → XP_006230305.1  INO80 complex subunit E isoform X2

    UniProtKB/TrEMBL
    A0A8I6G9J0
    Conserved Domains (1) summary
    pfam08537
    Location:12 → 97
    NBP1; Fungal Nap binding protein NBP1

  9. XM_006230245.4 → XP_006230307.1  INO80 complex subunit E isoform X5

    UniProtKB/TrEMBL
    A0A8I6G9J0, A0A8L2UKE2
    Related
    ENSRNOP00000083835.2, ENSRNOT00000107197.2
    Conserved Domains (1) summary
    pfam08537
    Location:12 → 65
    NBP1; Fungal Nap binding protein NBP1

  10. XM_006230244.4 → XP_006230306.1  INO80 complex subunit E isoform X3

    UniProtKB/TrEMBL
    A0A8I6G9J0

  11. XM_039107436.1 → XP_038963364.1  INO80 complex subunit E isoform X12

    UniProtKB/TrEMBL
    A0A8I6A0H5, A6I9G5, A6I9G8

  12. XM_039107432.1 → XP_038963360.1  INO80 complex subunit E isoform X12

    UniProtKB/TrEMBL
    A0A8I6A0H5, A6I9G5, A6I9G8

  13. XM_039107430.2 → XP_038963358.1  INO80 complex subunit E isoform X10

  14. XM_017588993.3 → XP_017444482.1  INO80 complex subunit E isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYH2.1 GenPept UniProtKB/Swiss-Prot:Q6AYH2

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