U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nlrp10 NLR family, pyrin domain containing 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293426, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Nlrp10provided by RGD
Official Full Name
NLR family, pyrin domain containing 10provided by RGD
Primary source
RGD:1307387
See related
EnsemblRapid:ENSRNOG00000015082 AllianceGenome:RGD:1307387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nalp10
Summary
Predicted to enable ATP hydrolysis activity and GTPase activity. Predicted to be involved in several processes, including positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; positive regulation of cytokine production; and positive regulation of defense response. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and nucleus. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to human NLRP10 (NLR family pyrin domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 18.9), Lung (RPKM 7.6) and 5 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nlrp10 in Genome Data Viewer
Location:
1q33
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (172357648..172365205, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (162922806..162930363, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (173521412..173528969, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily A member 3 Neighboring gene olfactory receptor family 10 subfamily A member 3C Neighboring gene eukaryotic translation initiation factor 3, subunit F Neighboring gene TUB bipartite transcription factor Neighboring gene RIC3 acetylcholine receptor chaperone

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10. Murphy N, et al. Neuromolecular Med, 2014 Mar. PMID 24197756
  2. Involvement of NLRP10 in IL-1α induction of oral epithelial cells by periodontal pathogens. Lee SJ, et al. Innate Immun, 2017 Oct. PMID 28766990
  3. Epidermal NLRP10 contributes to contact hypersensitivity responses in mice. Damm A, et al. Eur J Immunol, 2016 Aug. PMID 27221772
  4. Three-dimensional structure of human NLRP10/PYNOD pyrin domain reveals a homotypic interaction site distinct from its mouse homologue. Su MY, et al. PLoS One, 2013. PMID 23861819, Free PMC Article
  5. NLRP10 enhances Shigella-induced pro-inflammatory responses. Lautz K, et al. Cell Microbiol, 2012 Oct. PMID 22672233

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to fungus ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T-helper 17 type immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-1 alpha production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of canonical inflammasome complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
NACHT, LRR and PYD domains-containing protein 10
Names
NACHT, leucine rich repeat and PYD containing 10

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106291.1 → NP_001099761.1  NACHT, LRR and PYD domains-containing protein 10

    See identical proteins and their annotated locations for NP_001099761.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473956
    UniProtKB/TrEMBL
    A6I7U9, D3ZUA2
    Related
    ENSRNOP00000020393.3, ENSRNOT00000020393.6
    Conserved Domains (3) summary
    smart00382
    Location:161 → 298
    AAA; ATPases associated with a variety of cellular activities
    cd08321
    Location:10 → 88
    Pyrin_ASC-like; Pyrin Death Domain found in ASC
    pfam05729
    Location:165 → 316
    NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    172357648..172365205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools