Cblif cobalamin binding intrinsic factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cblifprovided by RGD
Official Full Name: cobalamin binding intrinsic factorprovided by RGD
Primary source: RGD:62084
See related: EnsemblRapid:ENSRNOG00000021001 AllianceGenome:RGD:62084
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gif
Summary: Enables cobalamin binding activity. Predicted to be involved in cobalamin transport. Predicted to be located in apical plasma membrane; endosome; and microvillus. Predicted to be active in extracellular space. Used to study gastritis. Human ortholog(s) of this gene implicated in congenital intrinsic factor deficiency and pernicious anemia. Orthologous to human CBLIF (cobalamin binding intrinsic factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 11.4), Brain (RPKM 4.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1q43

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (218030756..218045004)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (208605983..208620231)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (228118048..228132296)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Gif (e-PCR), detects polymorphism
- UniSTS:143207

D1Wox61 (e-PCR)
- UniSTS:239565

D1Wox62 (e-PCR)
- UniSTS:239566

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cargo receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables cargo receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables cobalamin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cobalamin binding	IDA Inferred from Direct Assay more info	PubMed
enables cobalamin binding	IEA Inferred from Electronic Annotation more info
enables cobalamin binding	ISO Inferred from Sequence Orthology more info
enables vitamin binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cobalamin transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cobalamin transport	IEA Inferred from Electronic Annotation more info
involved_in cobalamin transport	ISO Inferred from Sequence Orthology more info
involved_in cobalt ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cobalamin binding intrinsic factor

Names: IF; INF; gastric intrinsic factor; intrinsic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.