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Far1 fatty acyl CoA reductase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293173, updated on 4-Jan-2025

Summary

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Official Symbol
Far1provided by RGD
Official Full Name
fatty acyl CoA reductase 1provided by RGD
Primary source
RGD:1306647
See related
EnsemblRapid:ENSRNOG00000013176 AllianceGenome:RGD:1306647
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mlstd2
Summary
Predicted to enable alcohol-forming long-chain fatty acyl-CoA reductase activity and alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in lipid biosynthetic process and long-chain fatty-acyl-CoA metabolic process. Predicted to be located in peroxisomal membrane. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctate type 4. Orthologous to human FAR1 (fatty acyl-CoA reductase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 225.1), Lung (RPKM 188.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Far1 in Genome Data Viewer
Location:
1q33
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (177078973..177140363)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (167644622..167705868)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (178351674..178412838)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene parathyroid hormone Neighboring gene enolase 1, pseudogene 9 Neighboring gene cytochrome c, somatic-like Neighboring gene uncharacterized LOC102548137 Neighboring gene methionyl aminopeptidase 2, pseudogene 3 Neighboring gene uncharacterized LOC134484911

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes. Marsh KG, et al. Am J Physiol Heart Circ Physiol, 2021 May 1. PMID 33666503, Free PMC Article
  2. Posttranslational regulation of fatty acyl-CoA reductase 1, Far1, controls ether glycerophospholipid synthesis. Honsho M, et al. J Biol Chem, 2010 Mar 19. PMID 20071337, Free PMC Article
  3. Topogenesis and homeostasis of fatty acyl-CoA reductase 1. Honsho M, et al. J Biol Chem, 2013 Nov 29. PMID 24108123, Free PMC Article
  4. Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. Cheng JB, et al. J Biol Chem, 2004 Sep 3. PMID 15220348, Free PMC Article
  5. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. Cheng JB, et al. J Biol Chem, 2004 Sep 3. PMID 15220349, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes.
    Title: The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol-forming long-chain fatty acyl-CoA reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables alcohol-forming long-chain fatty acyl-CoA reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ether lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ether lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ether lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid derivative metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerophospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerophospholipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in wax biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in wax biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in wax biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
fatty acyl-CoA reductase 1
Names
male sterility domain containing 2
male sterility domain-containing protein 2
NP_001011933.1
XP_006230079.1
XP_006230080.1
XP_006230082.1
XP_038962380.1
XP_038962381.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011933.1 → NP_001011933.1  fatty acyl-CoA reductase 1

    See identical proteins and their annotated locations for NP_001011933.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082015
    UniProtKB/Swiss-Prot
    Q66H50
    UniProtKB/TrEMBL
    A6I889
    Conserved Domains (3) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    PLN02996
    Location:2 → 446
    PLN02996; fatty acyl-CoA reductase
    pfam03015
    Location:371 → 447
    Sterile; Male sterility protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    177078973..177140363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230017.5 → XP_006230079.1  fatty acyl-CoA reductase 1 isoform X1

    See identical proteins and their annotated locations for XP_006230079.1

    UniProtKB/TrEMBL
    A0A096MJW2, A6I887
    Related
    ENSRNOP00000018532.8, ENSRNOT00000018532.8
    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

  2. XM_039106452.2 → XP_038962380.1  fatty acyl-CoA reductase 1 isoform X1

    UniProtKB/TrEMBL
    A0A096MJW2, A6I887
    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

  3. XM_006230020.5 → XP_006230082.1  fatty acyl-CoA reductase 1 isoform X2

    See identical proteins and their annotated locations for XP_006230082.1

    UniProtKB/Swiss-Prot
    Q66H50
    UniProtKB/TrEMBL
    A6I889
    Related
    ENSRNOP00000068284.2, ENSRNOT00000076430.4
    Conserved Domains (3) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    PLN02996
    Location:2 → 446
    PLN02996; fatty acyl-CoA reductase
    pfam03015
    Location:371 → 447
    Sterile; Male sterility protein

  4. XM_039106453.2 → XP_038962381.1  fatty acyl-CoA reductase 1 isoform X3

    Conserved Domains (1) summary
    cd05236
    Location:11 → 319
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs

  5. XM_006230018.5 → XP_006230080.1  fatty acyl-CoA reductase 1 isoform X1

    See identical proteins and their annotated locations for XP_006230080.1

    UniProtKB/TrEMBL
    A0A096MJW2, A6I887
    Conserved Domains (2) summary
    cd05236
    Location:11 → 330
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H50.1 GenPept UniProtKB/Swiss-Prot:Q66H50

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