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Nars2 asparaginyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 293128, updated on 27-Nov-2024

Summary

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Official Symbol
Nars2provided by RGD
Official Full Name
asparaginyl-tRNA synthetase 2, mitochondrialprovided by RGD
Primary source
RGD:1305145
See related
EnsemblRapid:ENSRNOG00000011476 AllianceGenome:RGD:1305145
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305145
Summary
Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 93.8), Adrenal (RPKM 82.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nars2 in Genome Data Viewer
Location:
1q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (160711680..160823311)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (151300446..151412086)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (161922132..162035817)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene teneurin transmembrane protein 4 Neighboring gene uncharacterized LOC134483756 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134485154 Neighboring gene uncharacterized LOC134485155 Neighboring gene uncharacterized LOC108349194 Neighboring gene GRB2-associated binding protein 2 Neighboring gene ubiquitin specific peptidase 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome. Simon M, et al. PLoS Genet, 2015 Mar. PMID 25807530, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC125113

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables asparagine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in asparaginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
asparaginyl-tRNA synthetase
Names
Nars2, similar to CG6796-PA
asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)
probable asparagine--tRNA ligase, mitochondrial
probable asparaginyl-tRNA synthetase, mitochondrial
NP_001030093.1
NP_001385667.1
XP_038961877.1
XP_038961884.1
XP_063141059.1
XP_063141061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034921.2 → NP_001030093.1  asparaginyl-tRNA synthetase isoform 2

    See identical proteins and their annotated locations for NP_001030093.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1LNQ5, Q3SWT9
    Related
    ENSRNOP00000015784.7, ENSRNOT00000015784.8
    Conserved Domains (2) summary
    cd04318
    Location:44 → 120
    EcAsnRS_like_N; EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB ...
    cl00268
    Location:133 → 389
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

  2. NM_001398738.1 → NP_001385667.1  asparaginyl-tRNA synthetase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6A5J1
    Related
    ENSRNOP00000087263.1, ENSRNOT00000109218.2
    Conserved Domains (1) summary
    PRK03932
    Location:27 → 474
    asnC; asparaginyl-tRNA synthetase; Validated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    160711680..160823311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284991.1 → XP_063141061.1  asparaginyl-tRNA synthetase isoform X4

  2. XM_063284989.1 → XP_063141059.1  asparaginyl-tRNA synthetase isoform X1

    UniProtKB/TrEMBL
    A0A0G2K7D7
    Related
    ENSRNOP00000111699.1, ENSRNOT00000151636.1

  3. XM_039105949.2 → XP_038961877.1  asparaginyl-tRNA synthetase isoform X2

    Conserved Domains (1) summary
    PRK03932
    Location:27 → 305
    asnC; asparaginyl-tRNA synthetase; Validated

  4. XM_039105956.2 → XP_038961884.1  asparaginyl-tRNA synthetase isoform X3

    UniProtKB/TrEMBL
    Q5I0C6
    Conserved Domains (1) summary
    PRK03932
    Location:14 → 257
    asnC; asparaginyl-tRNA synthetase; Validated
Nucleotide Protein Strain
Heading Accession and Version

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