Adamts17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adamts17provided by RGD
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 17provided by RGD
Primary source: RGD:1308783
See related: EnsemblRapid:ENSRNOG00000037080 AllianceGenome:RGD:1308783
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS17 (ADAM metallopeptidase with thrombospondin type 1 motif 17). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 65.0), Kidney (RPKM 15.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (129856062..130178430)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (120445800..120768204)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (127802872..128126764)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142493 (e-PCR)
- UniSTS:231740

D1Mco57 (e-PCR)
- UniSTS:518555

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 17

Names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432137.1 → NP_001419066.1 A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZWR9, D4ABB3
NM_001432138.1 → NP_001419067.1 A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001432139.1 → NP_001419068.1 A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

129856062..130178430

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094338.2 → XP_038950266.1 A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform X2

Conserved Domains (7) summary

smart00209
Location:544 → 596

TSP1; Thrombospondin type 1 repeats

cd04273
Location:230 → 447

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:698 → 808

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:35 → 179

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:464 → 531

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:834 → 886

TSP1_ADAMTS; Thrombospondin type 1 domain

cl00292
Location:168 → 244

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
XM_218753.11 → XP_218753.6 A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform X1

Related

ENSRNOP00000052730.4, ENSRNOT00000055877.5

Conserved Domains (8) summary

smart00209
Location:544 → 596

TSP1; Thrombospondin type 1 repeats

cd04273
Location:230 → 447

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam00090
Location:893 → 946

TSP_1; Thrombospondin type 1 domain

pfam01421
Location:230 → 447

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:61 → 179

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:698 → 808

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1080 → 1106

PLAC; PLAC (protease and lacunin) domain

cl00292
Location:168 → 244

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.