Pepd peptidase D [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pepdprovided by RGD
Full Name: peptidase Dprovided by RGD
Primary source: RGD:1594571
See related: EnsemblRapid:ENSRNOG00000052945 AllianceGenome:RGD:1594571
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable proline dipeptidase activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 1510.9), Liver (RPKM 176.0) and 8 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (96673624..96818197)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (87536650..87681233)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (90820670..91285128)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In summary, these data suggest that maintenance of levels of proline, other amino acids and peptides containing proline in the rat brain is regulated by prolidase isoenzymes.
Title: Activity of prolidase isoenzymes in the rat brain: subcellular and regional distribution during development.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

D1Rat189 (e-PCR)
- UniSTS:118549

D1Got92 (e-PCR)
- UniSTS:112166

GDB:362661 (e-PCR)
- UniSTS:156752

AU048004 (e-PCR)
- UniSTS:109968

D1Got263 (e-PCR)
- UniSTS:112553

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables proline dipeptidase activity	IEA Inferred from Electronic Annotation more info
enables proline dipeptidase activity	ISO Inferred from Sequence Orthology more info
enables proline dipeptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: xaa-Pro dipeptidase

Names: X-Pro dipeptidase; imidodipeptidase; prolidase; proline dipeptidase; xaa-Pro dipeptidase-like

NP_001009641.1

EC 3.4.13.9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009641.2 → NP_001009641.1 xaa-Pro dipeptidase

See identical proteins and their annotated locations for NP_001009641.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q5I0D7

UniProtKB/TrEMBL

A0A8I6A0W2

Related

ENSRNOP00000095277.2, ENSRNOT00000077404.3

Conserved Domains (3) summary

smart01011
Location:18 → 155

AMP_N; Aminopeptidase P, N-terminal domain

COG0006
Location:52 → 476

PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]

cd01087
Location:192 → 467

Prolidase; Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on ...