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Eif3k eukaryotic translation initiation factor 3, subunit K [ Rattus norvegicus (Norway rat) ]

Gene ID: 292762, updated on 27-Nov-2024

Summary

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Official Symbol
Eif3kprovided by RGD
Official Full Name
eukaryotic translation initiation factor 3, subunit Kprovided by RGD
Primary source
RGD:1309221
See related
EnsemblRapid:ENSRNOG00000020495 AllianceGenome:RGD:1309221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Eif3s12; PLAC-24
Summary
Predicted to enable RNA binding activity and ribosome binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 3 complex. Orthologous to human EIF3K (eukaryotic translation initiation factor 3 subunit K). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 516.6), Thymus (RPKM 505.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eif3k in Genome Data Viewer
Location:
1q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93387628..93397551, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84260127..84270051, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (87927142..87937033, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene uncharacterized LOC102550499 Neighboring gene calpain 12 Neighboring gene actinin alpha 4 Neighboring gene mitogen activated protein kinase kinase kinase kinase 1 Neighboring gene ryanodine receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k. De Martelaere K, et al. Cell Signal, 2007 Feb. PMID 16935469
  2. PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact. Karki S, et al. Mol Biol Cell, 2002 May. PMID 12006665, Free PMC Article
  3. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG. Annu Rev Biochem, 2014. PMID 24499181
  4. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Lee AS, et al. Nature, 2015 Jun 4. PMID 25849773, Free PMC Article
  5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Damoc E, et al. Mol Cell Proteomics, 2007 Jul. PMID 17322308

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These observations suggest that PLAC-24 may play a role in the transport and the stabilisation of newly synthesised 5-HT(7) receptor towards the plasma membrane.
    Title: Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k.
  2. identification of a novel 24-kDa protein (Plac-24) that binds directly to dynein intermediate chain.
    Title: PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit K
Names
eukaryotic translation initiation factor 3, subunit 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398703.1 → NP_001385632.1  eukaryotic translation initiation factor 3 subunit K

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZX76, A6J9M3
    Related
    ENSRNOP00000083732.1, ENSRNOT00000118913.2
    Conserved Domains (1) summary
    pfam10075
    Location:61 → 189
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    93387628..93397551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283417.1 → XP_063139487.1  eukaryotic translation initiation factor 3 subunit K isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIB7
    Related
    ENSRNOP00000094716.1, ENSRNOT00000112033.2

  2. XM_039104247.2 → XP_038960175.1  eukaryotic translation initiation factor 3 subunit K isoform X2

    Conserved Domains (1) summary
    cl24019
    Location:61 → 118
    CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106242.1: Suppressed sequence

    Description
    NM_001106242.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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