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Spr sepiapterin reductase [ Rattus norvegicus (Norway rat) ]

Gene ID: 29270, updated on 27-Nov-2024

Summary

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Official Symbol
Sprprovided by RGD
Official Full Name
sepiapterin reductaseprovided by RGD
Primary source
RGD:3753
See related
EnsemblRapid:ENSRNOG00000015455 AllianceGenome:RGD:3753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables sepiapterin reductase (NADP+) activity. Involved in positive regulation of cell population proliferation and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 299.0), Liver (RPKM 294.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q34
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119229447..119233320, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (117671948..117676292, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (116912343..116916073, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486598 Neighboring gene uncharacterized LOC134486599 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486600 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effect of antisense oligodeoxynucleotide for sepiapterin reductase on the viability of PC12 cells in the presence of exogenous carbonyl compounds. Fujimoto K, et al. Chem Biol Interact, 2003 Feb 1. PMID 12604243
  2. Immunological evidence for the requirement of sepiapterin reductase for tetrahydrobiopterin biosynthesis in brain. Levine RA, et al. J Neurochem, 1990 Apr. PMID 2179471
  3. Isolation and expression of rat liver sepiapterin reductase cDNA. Citron BA, et al. Proc Natl Acad Sci U S A, 1990 Aug. PMID 2201030, Free PMC Article
  4. The complete amino acid sequence of the mature form of rat sepiapterin reductase. Oyama R, et al. Biochem Biophys Res Commun, 1990 Dec 14. PMID 2260974
  5. Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase. Fujimoto K, et al. Biochim Biophys Acta, 1999 May 18. PMID 10350607

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions.
    Title: Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sepiapterin reductase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sepiapterin reductase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sepiapterin reductase (NADP+) activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-phenylalanine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within norepinephrine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pteridine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within serotonin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tetrahydrobiopterin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrobiopterin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tetrahydrobiopterin biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within tetrahydrobiopterin metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within voluntary musculoskeletal movement ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sepiapterin reductase
Names
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
NP_062054.1
XP_038963128.1
XP_038963129.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019181.2 → NP_062054.1  sepiapterin reductase

    See identical proteins and their annotated locations for NP_062054.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P18297
    UniProtKB/TrEMBL
    A0A8I5ZU80, B2RYK3
    Related
    ENSRNOP00000020749.4, ENSRNOT00000020749.8
    Conserved Domains (1) summary
    cl21454
    Location:9 → 261
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    119229447..119233320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107201.2 → XP_038963129.1  sepiapterin reductase isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:1 → 130
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_039107200.2 → XP_038963128.1  sepiapterin reductase isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:9 → 164
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18297.1 GenPept UniProtKB/Swiss-Prot:P18297

Gene LinkOut

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