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Qpctl glutaminyl-peptide cyclotransferase-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 292687, updated on 27-Nov-2024

Summary

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Official Symbol
Qpctlprovided by RGD
Official Full Name
glutaminyl-peptide cyclotransferase-likeprovided by RGD
Primary source
RGD:1308128
See related
EnsemblRapid:ENSRNOG00000015413 AllianceGenome:RGD:1308128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308128
Summary
Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Predicted to be located in Golgi apparatus. Orthologous to human QPCTL (glutaminyl-peptide cyclotransferase like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 46.3), Adrenal (RPKM 45.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Qpctl in Genome Data Viewer
Location:
1q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87916771..87925843, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78786730..78797956, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80046975..80057022, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene meiosis initiator Neighboring gene SIX homeobox 5 Neighboring gene F-box protein 46 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene EMAP like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. Huang KF, et al. J Biol Chem, 2011 Apr 8. PMID 21288892, Free PMC Article
  2. Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. Cynis H, et al. J Mol Biol, 2008 Jun 20. PMID 18486145
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutaminyl-peptide cyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminyl-peptide cyclotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutaminyl-peptide cyclotransferase-like protein
NP_001099700.1
XP_006228464.1
XP_038959895.1
XP_038959901.1
XP_063139247.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106230.1 → NP_001099700.1  glutaminyl-peptide cyclotransferase-like protein

    See identical proteins and their annotated locations for NP_001099700.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    B5DFI7, F7FB82
    Related
    ENSRNOP00000021200.4, ENSRNOT00000021200.7
    Conserved Domains (1) summary
    cd03880
    Location:80 → 380
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    87916771..87925843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103973.2 → XP_038959901.1  glutaminyl-peptide cyclotransferase-like protein isoform X3

    UniProtKB/TrEMBL
    A6J8K1
    Conserved Domains (1) summary
    cl14876
    Location:82 → 263
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. XM_006228402.5 → XP_006228464.1  glutaminyl-peptide cyclotransferase-like protein isoform X1

    Conserved Domains (1) summary
    cd03880
    Location:80 → 341
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

  3. XM_039103967.2 → XP_038959895.1  glutaminyl-peptide cyclotransferase-like protein isoform X2

    UniProtKB/TrEMBL
    A6J8K1
    Conserved Domains (1) summary
    cl14876
    Location:82 → 296
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  4. XM_063283177.1 → XP_063139247.1  glutaminyl-peptide cyclotransferase-like protein isoform X4

RNA

  1. XR_005501477.2 RNA Sequence

  2. XR_005501480.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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