Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ercc1provided by RGD
Official Full Name: ERCC excision repair 1, endonuclease non-catalytic subunitprovided by RGD
Primary source: RGD:1306992
See related: EnsemblRapid:ENSRNOG00000017839 AllianceGenome:RGD:1306992
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity; TFIID-class transcription factor complex binding activity; and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in several processes, including response to cadmium ion; response to immobilization stress; and response to sucrose. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Predicted to be active in nucleus. Used to study lung carcinoma. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 70.5), Brain (RPKM 67.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88099308..88135966)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78971310..79007963)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80256973..80268198)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

ERCC1 (e-PCR)
- UniSTS:278346

BE120839 (e-PCR)
- UniSTS:247464

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to 3' overhang single-stranded DNA endodeoxyribonuclease activity	ISO Inferred from Sequence Orthology more info
contributes_to DNA binding	ISO Inferred from Sequence Orthology more info
enables TFIID-class transcription factor complex binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded DNA endodeoxyribonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within UV protection	ISO Inferred from Sequence Orthology more info
involved_in UV-damage excision repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within double-strand break repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in embryonic organ development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within germ cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within isotype switching	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in mitotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protection from non-homologous end joining at telomere	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of t-circle formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pyrimidine dimer repair by nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within replicative senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to X-ray	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to sucrose	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within syncytium formation	ISO Inferred from Sequence Orthology more info
involved_in t-circle formation	ISO Inferred from Sequence Orthology more info
involved_in telomeric DNA-containing double minutes formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ERCC4-ERCC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ERCC4-ERCC1 complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleotide-excision repair complex	ISO Inferred from Sequence Orthology more info
part_of nucleotide-excision repair factor 1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-excision repair factor 1 complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA excision repair protein ERCC-1

Names: excision repair cross-complementation group 1; excision repair cross-complementing 1; excision repair cross-complementing rodent repair deficiency, complementation group 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106228.1 → NP_001099698.1 DNA excision repair protein ERCC-1

See identical proteins and their annotated locations for NP_001099698.1

Status: PROVISIONAL

Source sequence(s)

CH473979

UniProtKB/TrEMBL

A0A8I6GI31, A6J8M3, D3ZAQ9

Related

ENSRNOP00000087227.2, ENSRNOT00000104471.2

Conserved Domains (2) summary

PRK00558
Location:251 → 291

uvrC; excinuclease ABC subunit UvrC

cd22325
Location:99 → 226

ERCC1_C-like; Central domain of ERCC1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

88099308..88135966

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103939.2 → XP_038959867.1 DNA excision repair protein ERCC-1 isoform X1

UniProtKB/TrEMBL

A0A8I6GI31, A6J8M3, D3ZAQ9

Related

ENSRNOP00000024113.5, ENSRNOT00000024113.7

Conserved Domains (2) summary

PRK00558
Location:251 → 291

uvrC; excinuclease ABC subunit UvrC

cd22325
Location:99 → 226

ERCC1_C-like; Central domain of ERCC1
XM_039103935.2 → XP_038959863.1 DNA excision repair protein ERCC-1 isoform X1

UniProtKB/TrEMBL

A0A8I6GI31, A6J8M3, D3ZAQ9

Conserved Domains (2) summary

PRK00558
Location:251 → 291

uvrC; excinuclease ABC subunit UvrC

cd22325
Location:99 → 226

ERCC1_C-like; Central domain of ERCC1
XM_006228395.5 → XP_006228457.1 DNA excision repair protein ERCC-1 isoform X1

See identical proteins and their annotated locations for XP_006228457.1

UniProtKB/TrEMBL

A0A8I6GI31, A6J8M3, D3ZAQ9

Conserved Domains (2) summary

PRK00558
Location:251 → 291

uvrC; excinuclease ABC subunit UvrC

cd22325
Location:99 → 226

ERCC1_C-like; Central domain of ERCC1
XM_006228396.4 → XP_006228458.1 DNA excision repair protein ERCC-1 isoform X1

See identical proteins and their annotated locations for XP_006228458.1

UniProtKB/TrEMBL

A0A8I6GI31, A6J8M3, D3ZAQ9

Conserved Domains (2) summary

PRK00558
Location:251 → 291

uvrC; excinuclease ABC subunit UvrC

cd22325
Location:99 → 226

ERCC1_C-like; Central domain of ERCC1