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Oscar osteoclast associated Ig-like receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 292537, updated on 2-Nov-2024

Summary

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Official Symbol
Oscarprovided by RGD
Official Full Name
osteoclast associated Ig-like receptorprovided by RGD
Primary source
RGD:1559897
See related
EnsemblRapid:ENSRNOG00000055716 AllianceGenome:RGD:1559897
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559897
Summary
Predicted to enable collagen receptor activity. Predicted to be involved in immune response-regulating signaling pathway. Predicted to act upstream of or within Fc-gamma receptor signaling pathway; multinuclear osteoclast differentiation; and positive regulation of bone resorption. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human OSCAR (osteoclast associated Ig-like receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 8.9), Lung (RPKM 8.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Oscar in Genome Data Viewer
Location:
1q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74521626..74529119)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65607214..65615395)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64182174..64188658)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TCF3 fusion partner Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 like 1 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. Kim N, et al. J Exp Med, 2002 Jan 21. PMID 11805147, Free PMC Article
  2. Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR). Ishikawa S, et al. Int Immunol, 2004 Jul. PMID 15184345
  3. OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. Barrow AD, et al. J Clin Invest, 2011 Sep. PMID 21841309, Free PMC Article
  4. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, et al. Front Pharmacol, 2020. PMID 33364953, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables collagen receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables collagen receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Fc-gamma receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in collagen-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within multinuclear osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
osteoclast-associated immunoglobulin-like receptor
Names
osteoclast associated receptor
osteoclast associated, immunoglobulin-like receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184973.1 → NP_001171902.1  osteoclast-associated immunoglobulin-like receptor precursor

    See identical proteins and their annotated locations for NP_001171902.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474101
    UniProtKB/TrEMBL
    A0A8I5ZN02, A6KS33
    Related
    ENSRNOP00000087390.2, ENSRNOT00000106643.2
    Conserved Domains (1) summary
    cl11960
    Location:36 → 129
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    74521626..74529119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103706.2 → XP_038959634.1  osteoclast-associated immunoglobulin-like receptor isoform X2

    Conserved Domains (2) summary
    cd00096
    Location:29 → 33
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28 → 114
    Ig; Immunoglobulin domain

  2. XM_006228020.5 → XP_006228082.1  osteoclast-associated immunoglobulin-like receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZN02, D3ZCA1
    Conserved Domains (1) summary
    cl11960
    Location:30 → 123
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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