Arg2 arginase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arg2provided by RGD
Official Full Name: arginase 2provided by RGD
Primary source: RGD:2151
See related: EnsemblRapid:ENSRNOG00000053811 AllianceGenome:RGD:2151
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables arginase activity and nitric-oxide synthase binding activity. Involved in several processes, including arginine catabolic process to ornithine; cellular response to cytokine stimulus; and cellular response to dexamethasone stimulus. Located in mitochondrion. Used to study hypertension. Biomarker of acute kidney failure; end stage renal disease; hypertension; and ureteral obstruction. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (arginase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 177.9), Uterus (RPKM 111.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (103669001..103694375)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (97936002..97961379)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (102311097..102338406)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway.
Title: Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway.
The present results indicate that Advanced glycation endproducts impairs endothelial-dependent vasodilation, and this effect is mediated via arginase overexpression and NADPH oxidase stimulation.
Title: Arginase overexpression and NADPH oxidase stimulation underlie impaired vasodilation induced by advanced glycation end products.
Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus
Title: Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus.
Intermittent hypoxia increases expression levels of arginase I and II proteins in adult rats.
Title: Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
arginase 1 and 2 inhibition augmented iNOS-dependent NO production that resulted in suppression of IL-1beta-induced vascular smooth muscle cell proliferation in a cGMP-dependent manner
Title: Arginase inhibition reduces interleukin-1β-stimulated vascular smooth muscle cell proliferation by increasing nitric oxide synthase-dependent nitric oxide production.
Arginase appears to be an essential modulator of the inflammatory response in the acute phase of a multiple sclerosis model.
Title: Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis.
findings indicate that the levels of arginase 1 and 2 varied among organs, suggesting that the arginase isoforms may play organ-specific roles in the urea cycle
Title: Immunohistochemical study of arginase 1 and 2 in various tissues of rats.
Arg-II upregulation in aging rat hearts contributes to age-related decreased contractile function.
Title: Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve.
investigation of arginase I/II expression in peritoneal macrophages of obese/lean Zucker diabetic rats, influence of arginine concentration on arginase expression in macrophages, and role of arginine/arginases in alpha-TNF/nitric oxide synthesis
Title: Arginine availability modulates arginine metabolism and TNFα production in peritoneal macrophages from Zucker Diabetic Fatty rats.
The data suggested that NO signaling is disrupted in neonatal rat pups exposed to even moderate hyperoxia due to increased arginase I and II activity and consequent decreased bioavailability of the substrate L-arginine.
Title: Role of arginase in impairing relaxation of lung parenchyma of hyperoxia-exposed neonatal rats.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Markers

RH133838 (e-PCR)
- UniSTS:217121

RH129742 (e-PCR)
- UniSTS:213035

BF386764 (e-PCR)
- UniSTS:243835

Arg2 (e-PCR), detects polymorphism
- UniSTS:527252

AU022422 (e-PCR)
- UniSTS:180412

RH141711 (e-PCR)
- UniSTS:223704

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arginase activity	IDA Inferred from Direct Assay more info	PubMed
enables arginase activity	IEA Inferred from Electronic Annotation more info
enables arginase activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric-oxide synthase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in arginine catabolic process to ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine catabolic process to ornithine	IDA Inferred from Direct Assay more info	PubMed
involved_in arginine catabolic process to ornithine	TAS Traceable Author Statement more info	PubMed
involved_in arginine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in arginine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-4	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-C motif) ligand 4 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine (C-C motif) ligand 4 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine (C-C motif) ligand 5 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-13 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage inflammatory protein 1 alpha production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage inflammatory protein 1 alpha production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric-oxide synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of striated muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type 2 immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in regulation of L-arginine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of nitric oxide biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of reactive oxygen species biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to herbicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mercury ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to selenium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in striated muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in urea cycle	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud development	IEA Inferred from Electronic Annotation more info
involved_in ureteric bud development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arginase-2, mitochondrial

Names: AII type II arginase; arginase II; arginase type II; kidney-type arginase; non-hepatic arginase; type II arginase

NP_062041.2

EC 3.5.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019168.2 → NP_062041.2 arginase-2, mitochondrial precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

O08701, P97539

UniProtKB/TrEMBL

A6HCG4, G3V7H6

Related

ENSRNOP00000073568.1, ENSRNOT00000083433.3

Conserved Domains (1) summary

cd09989
Location:26 → 321

Arginase; Arginase family