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Galnt2 polypeptide N-acetylgalactosaminyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292090, updated on 27-Nov-2024

Summary

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Official Symbol
Galnt2provided by RGD
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 2provided by RGD
Primary source
RGD:1310692
See related
EnsemblRapid:ENSRNOG00000019143 AllianceGenome:RGD:1310692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable manganese ion binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation and protein maturation. Predicted to be located in Golgi stack and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 107.1), Heart (RPKM 89.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Galnt2 in Genome Data Viewer
Location:
19q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (69110657..69222237)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (52213226..52324816)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57043858..57115123)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483659 Neighboring gene cytochrome c oxidase subunit VIc, pseudogene Neighboring gene piggyBac transposable element derived 5 Neighboring gene uncharacterized LOC108348970

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Type 2 diabetes mellitus facilitates endometrial hyperplasia progression by activating the proliferative function of mucin O-glycosylating enzyme GALNT2. Zhou X, et al. Biomed Pharmacother, 2020 Nov. PMID 33152927
  2. Dynamic association between the catalytic and lectin domains of human UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2. Fritz TA, et al. J Biol Chem, 2006 Mar 31. PMID 16434399
  3. Recycling of golgi-resident glycosyltransferases through the ER reveals a novel pathway and provides an explanation for nocodazole-induced Golgi scattering. Storrie B, et al. J Cell Biol, 1998 Dec 14. PMID 9852147, Free PMC Article
  4. Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2. Iwasaki H, et al. J Biol Chem, 2003 Feb 21. PMID 12438318
  5. Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β(1)-Adrenergic Receptor N-terminal Cleavage. Goth CK, et al. J Biol Chem, 2017 Mar 17. PMID 28167537, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Type 2 diabetes mellitus facilitates endometrial hyperplasia progression by activating the proliferative function of mucin O-glycosylating enzyme GALNT2.
    Title: Type 2 diabetes mellitus facilitates endometrial hyperplasia progression by activating the proliferative function of mucin O-glycosylating enzyme GALNT2.
  2. These results posit GALNT2 as a direct modulator of high density lipoprotein metabolism across mammals.
    Title: Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.
  3. Using a GalNAc-T2 knock-out rat model, this study shows that GalNAc-T2 co-regulates the metalloproteinase-mediated limited proteolysis of B1AR.
    Title: Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β(1)-Adrenergic Receptor N-terminal Cleavage.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in O-glycan processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 2
Names
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
NP_001099666.2
XP_038953585.1
XP_038953586.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106196.2 → NP_001099666.2  polypeptide N-acetylgalactosaminyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    Related
    ENSRNOP00000062956.2, ENSRNOT00000065431.3
    Conserved Domains (2) summary
    cd02510
    Location:138 → 433
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:445 → 562
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    69110657..69222237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097658.2 → XP_038953586.1  polypeptide N-acetylgalactosaminyltransferase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JU25
    Conserved Domains (2) summary
    cd02510
    Location:116 → 411
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:423 → 540
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. XM_039097657.1 → XP_038953585.1  polypeptide N-acetylgalactosaminyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JU25
    Related
    ENSRNOP00000068936.1, ENSRNOT00000080860.3
    Conserved Domains (2) summary
    cd02510
    Location:119 → 414
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:426 → 543
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
Nucleotide Protein Strain
Heading Accession and Version

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