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Galns galactosamine (N-acetyl)-6-sulfatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 292073, updated on 9-Dec-2024

Summary

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Official Symbol
Galnsprovided by RGD
Official Full Name
galactosamine (N-acetyl)-6-sulfataseprovided by RGD
Primary source
RGD:1565391
See related
EnsemblRapid:ENSRNOG00000014461 AllianceGenome:RGD:1565391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-acetylgalactosamine-6-sulfatase activity and arylsulfatase activity. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis IVA. Orthologous to human GALNS (galactosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 73.4), Lung (RPKM 47.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Galns in Genome Data Viewer
Location:
19q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67537175..67570900, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50628639..50662477, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55391004..55423328, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene chromatin licensing and DNA replication factor 1 Neighboring gene adenine phosphoribosyl transferase Neighboring gene trafficking protein particle complex subunit 2L Neighboring gene PABPN1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy. Bertolin J, et al. Nat Commun, 2021 Sep 9. PMID 34504088, Free PMC Article
  2. Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. Zito E, et al. EMBO Rep, 2005 Jul. PMID 15962010, Free PMC Article
  3. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy.
    Title: Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetylgalactosamine-6-sulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylgalactosamine-6-sulfatase activity ISO
Inferred from Sequence Orthology
more info
  
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfuric ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in lysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-acetylgalactosamine-6-sulfatase
Names
N-acetylgalactosamine-6-sulfate sulfatase
chondroitinase
chondroitinsulfatase
galNAc6S sulfatase
galactosamine (N-acetyl)-6-sulfate sulfatase
galactose-6-sulfate sulfatase
NP_001041316.1
XP_017456734.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047851.3 → NP_001041316.1  N-acetylgalactosamine-6-sulfatase precursor

    See identical proteins and their annotated locations for NP_001041316.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    Q32KJ6
    UniProtKB/TrEMBL
    A6IZT2
    Related
    ENSRNOP00000019528.3, ENSRNOT00000019528.6
    Conserved Domains (1) summary
    cd16157
    Location:31 → 496
    GALNS; galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    67537175..67570900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601245.3 → XP_017456734.2  N-acetylgalactosamine-6-sulfatase isoform X1

RNA

  1. XR_010059982.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32KJ6.1 GenPept UniProtKB/Swiss-Prot:Q32KJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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