Zc3h18 zinc finger CCCH-type containing 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zc3h18provided by RGD
Official Full Name: zinc finger CCCH-type containing 18provided by RGD
Primary source: RGD:1303257
See related: EnsemblRapid:ENSRNOG00000028501 AllianceGenome:RGD:1303257
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nhn1
Summary: Predicted to enable mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Predicted to be involved in RNA destabilization. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Orthologous to human ZC3H18 (zinc finger CCCH-type containing 18). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 99.3), Kidney (RPKM 81.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (67344422..67388400)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (50434864..50479855)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (55197348..55241800)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA cap binding complex binding	IEA Inferred from Electronic Annotation more info
enables mRNA cap binding complex binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in RNA destabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger CCCH domain-containing protein 18

Names: conserved nuclear protein Nhn1; nuclear protein NHN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001434427.1 → NP_001421356.1 zinc finger CCCH domain-containing protein 18 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q6TQE1, Q6TQE2

UniProtKB/TrEMBL

A0A8L2QI36, A6IZR5
NM_201416.2 → NP_958819.1 zinc finger CCCH domain-containing protein 18 isoform 2

See identical proteins and their annotated locations for NP_958819.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8L2QI36, A6IZR4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

67344422..67388400

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255758.5 → XP_006255820.1 zinc finger CCCH domain-containing protein 18 isoform X1

UniProtKB/TrEMBL

A0A8I6AKJ5, A0A8I6GGF2

Related

ENSRNOP00000093359.1, ENSRNOT00000101747.2
XM_006255759.5 → XP_006255821.1 zinc finger CCCH domain-containing protein 18 isoform X2

UniProtKB/TrEMBL

A0A8L2QI36
XM_006255760.5 → XP_006255822.1 zinc finger CCCH domain-containing protein 18 isoform X3

UniProtKB/TrEMBL

A0A140TAG3, A0A8I6GGF2

Related

ENSRNOP00000082197.2, ENSRNOT00000106092.2

Conserved Domains (1) summary

smart00356
Location:246 → 274

ZnF_C3H1; zinc finger