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Aars1 alanyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292023, updated on 4-Jan-2025

Summary

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Official Symbol
Aars1provided by RGD
Official Full Name
alanyl-tRNA synthetase 1provided by RGD
Primary source
RGD:1304832
See related
EnsemblRapid:ENSRNOG00000018404 AllianceGenome:RGD:1304832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aars
Summary
Enables several functions, including ATP binding activity; alanine-tRNA ligase activity; and tRNA binding activity. Involved in alanyl-tRNA aminoacylation. Predicted to be located in cytosol. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N; developmental and epileptic encephalopathy 29; leukodystrophy; and trichothiodystrophy. Orthologous to human AARS1 (alanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 469.9), Brain (RPKM 328.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aars1 in Genome Data Viewer
Location:
19q12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55906694..55930499)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38999130..39021152)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43193264..43215281, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene DEAD-box helicase 19A Neighboring gene DEAD-box helicase 19B Neighboring gene transfer RNA glycine (anticodon GCC) 11 Neighboring gene heterogeneous nuclear ribonucleoprotein C like 1 Neighboring gene exosome component 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Deficient activity of alanyl-tRNA synthetase underlies an autosomal recessive syndrome of progressive microcephaly, hypomyelination, and epileptic encephalopathy. Nakayama T, et al. Hum Mutat, 2017 Oct. PMID 28493438, Free PMC Article
  2. Alanyl-tRNA synthetase from Escherichia coli, Bombyx mori and Ratus ratus. Existence of common structural features. Dignam JD, et al. Eur J Biochem, 1991 May 23. PMID 2040280
  3. Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair. Sun L, et al. J Am Chem Soc, 2016 Oct 5. PMID 27622773, Free PMC Article
  4. Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy. Liu Y, et al. Proc Natl Acad Sci U S A, 2014 Dec 9. PMID 25422440, Free PMC Article
  5. Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Guo M, et al. Nature, 2009 Dec 10. PMID 20010690, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Ser-tRNA(Ala) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables Ser-tRNA(Ala) hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alanine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alanine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables aminoacyl-tRNA editing activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacyl-tRNA editing activity ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA editing activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide lactyltransferase (ATP-dependent) activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide lactyltransferase (ATP-dependent) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alanyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within alanyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in alanyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signal transduction by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cytoplasmic translational fidelity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
alanine--tRNA ligase, cytoplasmic
Names
alaRS
alanyl-tRNA synthetase, cytoplasmic
protein lactyltransferase AARS1
NP_001093987.1
XP_006255644.1
XP_006255645.1
XP_063134010.1
XP_063134011.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100517.2 → NP_001093987.1  alanine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_001093987.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    A6IZ80, P50475, Q4G057
    Conserved Domains (1) summary
    PLN02900
    Location:6 → 961
    PLN02900; alanyl-tRNA synthetase

  2. NM_001434414.1 → NP_001421343.1  alanine--tRNA ligase, cytoplasmic

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    A6IZ80, P50475, Q4G057

  3. NM_001434415.1 → NP_001421344.1  alanine--tRNA ligase, cytoplasmic

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    A6IZ80, P50475, Q4G057

  4. NM_001434416.1 → NP_001421345.1  alanine--tRNA ligase, cytoplasmic

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    A6IZ80, P50475, Q4G057

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    55906694..55930499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277940.1 → XP_063134010.1  alanine--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/Swiss-Prot
    A6IZ80, P50475, Q4G057
    Related
    ENSRNOP00000025051.5, ENSRNOT00000025052.7

  2. XM_006255583.5 → XP_006255645.1  alanine--tRNA ligase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_006255645.1

    UniProtKB/Swiss-Prot
    A6IZ80, P50475, Q4G057
    Conserved Domains (1) summary
    PLN02900
    Location:6 → 961
    PLN02900; alanyl-tRNA synthetase

  3. XM_063277941.1 → XP_063134011.1  alanine--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/Swiss-Prot
    A6IZ80, P50475, Q4G057

  4. XM_006255582.5 → XP_006255644.1  alanine--tRNA ligase, cytoplasmic isoform X1

    Conserved Domains (1) summary
    PLN02900
    Location:6 → 961
    PLN02900; alanyl-tRNA synthetase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50475.3 GenPept UniProtKB/Swiss-Prot:P50475

Gene LinkOut

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