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Txnl4b thioredoxin-like 4B [ Rattus norvegicus (Norway rat) ]

Gene ID: 292008, updated on 27-Nov-2024

Summary

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Official Symbol
Txnl4bprovided by RGD
Official Full Name
thioredoxin-like 4Bprovided by RGD
Primary source
RGD:1305127
See related
EnsemblRapid:ENSRNOG00000021379 AllianceGenome:RGD:1305127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305127
Summary
Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of U4/U6 x U5 tri-snRNP complex; U5 snRNP; and spliceosomal complex. Orthologous to human TXNL4B (thioredoxin like 4B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 41.1), Kidney (RPKM 40.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Txnl4b in Genome Data Viewer
Location:
19q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (54439686..54449777)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (37530157..37539827)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (42101081..42110223, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483362 Neighboring gene polyamine modulated factor 1 binding protein 1 Neighboring gene uncharacterized LOC134483363 Neighboring gene DEAH-box helicase 38 Neighboring gene haptoglobin Neighboring gene dihydroorotate dehydrogenase Neighboring gene polycystin 1 like 3, transient receptor potential channel interacting Neighboring gene IST1 factor associated with ESCRT-III

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109322

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thioredoxin-like protein 4B
Names
Dim1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013891.2 → NP_001013913.1  thioredoxin-like protein 4B isoform 1

    See identical proteins and their annotated locations for NP_001013913.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    F7FL88, Q5FVI5
    Conserved Domains (1) summary
    cd02986
    Location:10 → 123
    DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...

  2. NM_001434407.1 → NP_001421336.1  thioredoxin-like protein 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019

RNA

  1. NR_197783.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    54439686..54449777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255579.5 → XP_006255641.1  thioredoxin-like protein 4B isoform X1

    UniProtKB/TrEMBL
    F7FL88, Q5FVI5
    Related
    ENSRNOP00000030193.3, ENSRNOT00000034676.6
    Conserved Domains (1) summary
    cd02986
    Location:10 → 123
    DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...

  2. XM_017601235.3 → XP_017456724.1  thioredoxin-like protein 4B isoform X2

    Conserved Domains (1) summary
    cl00388
    Location:1 → 69
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. XM_063277930.1 → XP_063134000.1  thioredoxin-like protein 4B isoform X1

    UniProtKB/TrEMBL
    F7FL88, Q5FVI5

  4. XM_063277931.1 → XP_063134001.1  thioredoxin-like protein 4B isoform X2

RNA

  1. XR_361828.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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