Inhba inhibin subunit beta A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Inhbaprovided by RGD
Official Full Name: inhibin subunit beta Aprovided by RGD
Primary source: RGD:62074
See related: EnsemblRapid:ENSRNOG00000014320 AllianceGenome:RGD:62074
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; peptide hormone binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; cellular response to decreased oxygen levels; and positive regulation of DNA-templated transcription. Located in extracellular space. Part of inhibin A complex. Biomarker of congestive heart failure; myocardial infarction; retinal degeneration; and rheumatic heart disease. Orthologous to human INHBA (inhibin subunit beta A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 68.8), Uterus (RPKM 14.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (53787159..53810942, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (49091635..49111573, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (51894869..51919998, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activin A overexpression promotes rat follicular development through SCF-kit-mediated cell signals.
Title: Activin A overexpression promotes rat follicular development through SCF-kit-mediated cell signals.
Plasma activin A doubled in unilateral ureter obstruction rats after 10 days while no changes were seen in unilateral nephrectomized rats, suggesting secretion of activin A from the obstructed kidney with potentially systemic effects on CKD-MBD.
Title: Klotho and activin A in kidney injury: plasma Klotho is maintained in unilateral obstruction despite no upregulation of Klotho biosynthesis in the contralateral kidney.
These data suggest that ghrelin inhibits myocardial fibrosis, attenuates left ventricular remodeling, and eventually improves cardiac function by adjusting Act A/FS imbalance.
Title: Ghrelin suppresses cardiac fibrosis of post-myocardial infarction heart failure rats by adjusting the activin A-follistatin imbalance.
The activation of JNK and p38 MAPK pathways in OGD-treated PC12 cells was suppressed by exogenous Act A and enhanced by ActRIIA-Ab. Together, our results suggest that Act A/Smads signaling pathway negatively regulates OGD-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells.
Title: CHOP deficiency inhibits methylglyoxal-induced endothelial dysfunction.
Activin A/Smad 2/3 and activin A/ERK1/2 signaling pathway may be involved in isoflurane induced postconditioning induced neuroprotection.
Title: Effects of activin A and its downstream ERK1/2 in oxygen and glucose deprivation after isoflurane-induced postconditioning.
a self-amplifying loop existed in Act A signaling in PC12 cells
Title: Noncanonical Activin A Signaling in PC12 Cells: A Self-Limiting Feedback Loop.
Activin A regulates growth of gastro-intestinal epithelial cells by mediating epithelial-mesenchymal interaction.
Title: Activin A regulates growth of gastro-intestinal epithelial cells by mediating epithelial-mesenchymal interaction.
These data suggest that activin A produced by interstitial fibroblasts acts as a potent profibrotic factor during renal fibrosis. Blockade of activin A action may be a novel approach for the prevention of renal fibrosis progression.
Title: Follistatin, an activin antagonist, ameliorates renal interstitial fibrosis in a rat model of unilateral ureteral obstruction.
ActA transmembrance signaling is a part of the positive feed-back loop for extracellular ActA secretion.
Title: Endogenous protection derived from activin A/Smads transduction loop stimulated via ischemic injury in PC12 cells.
retinoid signalling can potently suppress activin-induced proliferation by antagonising G1 phase progression and entry into the cell cycle.
Title: Retinoic acid promotes Sertoli cell differentiation and antagonises activin-induced proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (38)

General gene information

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Markers

UniSTS:496691 (e-PCR)
- UniSTS:496691

Inhba (e-PCR), detects polymorphism
- UniSTS:496691

UniSTS:143589 (e-PCR)
- UniSTS:143589

Inhba (e-PCR), detects polymorphism
- UniSTS:143589

INHBA-STS (e-PCR), detects polymorphism
- UniSTS:253169

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables type II activin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GABAergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Sertoli cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within androgen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within androst-4-ene-3,17-dione biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac fibroblast cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cholesterol	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to follicle-stimulating hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxygen-glucose deprivation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine-mediated signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in eyelid development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in eyelid development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in hair follicle development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in hemoglobin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hemoglobin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ovulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ovulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase III	IEP Inferred from Expression Pattern more info	PubMed
involved_in progesterone secretion	ISO Inferred from Sequence Orthology more info
involved_in progesterone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of follicle-stimulating hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to aldosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in striatal medium spiny neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of activin A complex	ISO Inferred from Sequence Orthology more info
part_of activin A complex	ISS Inferred from Sequence or Structural Similarity more info
part_of enzyme activator complex	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of inhibin A complex	IDA Inferred from Direct Assay more info	PubMed
part_of inhibin A complex	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inhibin beta A chain

Names: activin A; activin beta-A chain; inhibin beta A subunit; inhibin beta-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017128.2 → NP_058824.1 inhibin beta A chain preproprotein

See identical proteins and their annotated locations for NP_058824.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

P18331

UniProtKB/TrEMBL

A6K9B0

Related

ENSRNOP00000019272.2, ENSRNOT00000019272.7

Conserved Domains (2) summary

cd19404
Location:317 → 424

TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins

cl02928
Location:56 → 236

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

53787159..53810942 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276286.1 → XP_063132356.1 inhibin beta A chain isoform X1

UniProtKB/Swiss-Prot

P18331

UniProtKB/TrEMBL

A6K9B0
XM_063276287.1 → XP_063132357.1 inhibin beta A chain isoform X1

UniProtKB/Swiss-Prot

P18331

UniProtKB/TrEMBL

A6K9B0
XM_008771712.4 → XP_008769934.1 inhibin beta A chain isoform X1

See identical proteins and their annotated locations for XP_008769934.1

UniProtKB/Swiss-Prot

P18331

UniProtKB/TrEMBL

A6K9B0

Conserved Domains (2) summary

cd19404
Location:317 → 424

TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins

cl02928
Location:56 → 236

TGFb_propeptide; TGF-beta propeptide
XM_006254001.5 → XP_006254063.1 inhibin beta A chain isoform X1

See identical proteins and their annotated locations for XP_006254063.1

UniProtKB/Swiss-Prot

P18331

UniProtKB/TrEMBL

A6K9B0

Conserved Domains (2) summary

cd19404
Location:317 → 424

TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins

cl02928
Location:56 → 236

TGFb_propeptide; TGF-beta propeptide