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Il18 interleukin 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29197, updated on 4-Jan-2025

Summary

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Official Symbol: Il18provided by RGD
Official Full Name: interleukin 18provided by RGD
Primary source: RGD:2889
See related: EnsemblRapid:ENSRNOG00000009848 AllianceGenome:RGD:2889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IL-18; IL-1 gamma
Summary: Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane and extracellular space. Used to study brain edema; heart disease; status epilepticus; steatotic liver disease; and vasculitis. Biomarker of several diseases, including artery disease (multiple); cardiac arrest; ischemia (multiple); lung disease (multiple); and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Spleen (RPKM 217.6), Adrenal (RPKM 216.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Il18 in Genome Data Viewer

Location:: 8q23

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (59802072..59829275)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (50904630..50932887)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (55009666..55016286)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder.
Title: IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder.
PDGF-beta and IL-18 Expressions on Carcinoma Cervical by Rhodomyrtus tomentosa.
Title: PDGF-β and IL-18 Expressions on Carcinoma Cervical by Rhodomyrtus tomentosa.
Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1.
Title: Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1.
Protective role of irbesartan against cyclophosphamide-induced testicular damage in rats via up-regulating PPAR-gamma signaling and ameliorating NF-kappaB/NLRP3/IL-18 inflammatory axis.
Title: Protective role of irbesartan against cyclophosphamide-induced testicular damage in rats via up-regulating PPAR-γ signaling and ameliorating NF-κB/NLRP3/IL-18 inflammatory axis.
[Effect of transcutaneous auricular vagus nerve stimulation on the expression of TLR4MyD88IL-18 protein in the prefrontal cortex of depression rats].
Title: [Effect of transcutaneous auricular vagus nerve stimulation on the expression of TLR4、MyD88、IL-18 protein in the prefrontal cortex of depression rats].
Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine.
Title: Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine.
Elevated intracranial pressure induces IL1beta and IL18 overproduction via activation of the NLRP3 inflammasome in microglia of ischemic adult rats.
Title: Elevated intracranial pressure induces IL‑1β and IL‑18 overproduction via activation of the NLRP3 inflammasome in microglia of ischemic adult rats.
MHC/class-II-positive cells inhibit corticosterone of adrenal gland cells in experimental arthritis: a role for IL-1beta, IL-18, and the inflammasome.
Title: MHC/class-II-positive cells inhibit corticosterone of adrenal gland cells in experimental arthritis: a role for IL-1β, IL-18, and the inflammasome.
Authors show that neuron-derived IL-18 signaling controls tissue-wide intestinal immunity and has profound consequences on the mucosal barrier and invasive bacterial killing.
Title: Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity.
IL18 and the related markers were closely associated with the occurrence and development of deep venous thrombosis.
Title: Correlation between the expression of IL‑18 and deep venous thrombosis.

Submit: New GeneRIF Correction See all GeneRIFs (60)

General gene information

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Markers

Il18 (e-PCR), detects polymorphism
- UniSTS:463948

Il18 (e-PCR), detects polymorphism
- UniSTS:502663

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables interleukin-18 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-18 receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-18 receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T-helper 1 type immune response	IEA Inferred from Electronic Annotation more info
involved_in T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in T-helper 1 type immune response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to parathyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide hormone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in digestive tract morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of skin barrier	IEA Inferred from Electronic Annotation more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in interleukin-18-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-18-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in learning or memory	TAS Traceable Author Statement more info	PubMed
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in natural killer cell activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NK T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NK T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 2 cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood vessel remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-1 beta production	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage derived foam cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of male germ cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of circadian sleep/wake cycle, non-REM sleep	TAS Traceable Author Statement more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in sleep	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-18

Names: IFN-gamma-inducing factor; interferon gamma-inducing factor; interleukin-1 gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019165.2 → NP_062038.2 interleukin-18

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

O88749, P97636, P97637, Q541E6

UniProtKB/TrEMBL

A0A8I5ZXP8

Conserved Domains (1) summary

cl00094
Location:77 → 184

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

59802072..59829275

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080940.2 → XP_038936868.1 interleukin-18 isoform X3

UniProtKB/Swiss-Prot

O88749, P97636, P97637, Q541E6

UniProtKB/TrEMBL

A0A8I5ZXP8

Conserved Domains (1) summary

cl00094
Location:77 → 184

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_039080944.2 → XP_038936872.1 interleukin-18 isoform X3

UniProtKB/Swiss-Prot

O88749, P97636, P97637, Q541E6

UniProtKB/TrEMBL

A0A8I5ZXP8

Related

ENSRNOP00000082676.2, ENSRNOT00000108779.2

Conserved Domains (1) summary

cl00094
Location:77 → 184

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
XM_063265005.1 → XP_063121075.1 interleukin-18 isoform X3

UniProtKB/Swiss-Prot

O88749, P97636, P97637, Q541E6

UniProtKB/TrEMBL

A0A8I5ZXP8
XM_063265008.1 → XP_063121078.1 interleukin-18 isoform X3

UniProtKB/Swiss-Prot

O88749, P97636, P97637, Q541E6

UniProtKB/TrEMBL

A0A8I5ZXP8
XM_063265004.1 → XP_063121074.1 interleukin-18 isoform X3

UniProtKB/Swiss-Prot

O88749, P97636, P97637, Q541E6

UniProtKB/TrEMBL

A0A8I5ZXP8

Related

ENSRNOP00000013093.8, ENSRNOT00000013093.8
XM_063265003.1 → XP_063121073.1 interleukin-18 isoform X1

UniProtKB/Swiss-Prot

O88749, P97636, P97637, Q541E6
XM_063265006.1 → XP_063121076.1 interleukin-18 isoform X3

UniProtKB/Swiss-Prot

O88749, P97636, P97637, Q541E6

UniProtKB/TrEMBL

A0A8I5ZXP8
XM_039080945.2 → XP_038936873.2 interleukin-18 isoform X2

UniProtKB/Swiss-Prot

O88749, P97636, P97637, Q541E6
XM_039080947.1 → XP_038936875.1 interleukin-18 isoform X4

Conserved Domains (1) summary

cl00094
Location:30 → 137

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).