Pdyn prodynorphin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdynprovided by RGD
Official Full Name: prodynorphinprovided by RGD
Primary source: RGD:62054
See related: EnsemblRapid:ENSRNOG00000026036 AllianceGenome:RGD:62054
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable opioid receptor binding activity. Involved in response to immobilization stress and response to nicotine. Located in several cellular components, including dendritic spine; dense core granule; and neuronal cell body. Is active in neuronal dense core vesicle lumen and synaptic vesicle. Used to study depressive disorder. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; brain disease (multiple); cocaine abuse; and morphine dependence. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; amphetamine abuse; drug dependence (multiple); and spinocerebellar ataxia type 23. Orthologous to human PDYN (prodynorphin). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Adrenal (RPKM 160.3), Brain (RPKM 64.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (137354161..137366503, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (116900990..116913334, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (122194327..122206671, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer.
Title: Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer.
Dynorphin participates in interaction between depression and non-erosive reflux disease.
Title: Dynorphin participates in interaction between depression and non-erosive reflux disease.
Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides.
Title: Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides.
food restriction-related negative energy balance causes pubertal failure with suppression of arcuate nucleus Kiss1 and Pdyn expression and then subsequent gonadotropin secretion and ovarian function, while the positive energetic cues trigger puberty onset via an increase in Kiss1 and Pdyn expression and thus gonadotropin secretion and follicular development in female rats
Title: Ad libitum feeding triggers puberty onset associated with increases in arcuate Kiss1 and Pdyn expression in growth-retarded rats.
Central injection of orexin A upregulated hypothalamic dynorphin expression.
Title: Central Orexin A Affects Reproductive Axis by Modulation of Hypothalamic Kisspeptin/Neurokinin B/Dynorphin Secreting Neurons in the Male Wistar Rats.
The different impacts of diverse long-term exercise intensities on the male pituitary-gonadal axis maybe relay by the various changes in hypothalamic Nkb and Pdyn gene expressions.
Title: Various responses of male pituitary-gonadal axis to different intensities of long-term exercise: Role of expression of KNDYrelated genes.
This study demonstrated that the Pdyn-miR365 interaction in the NAcSh directly influences novelty-seeking exploratory behavior and facilitates self-administration of natural reward.
Title: A Functional 3'UTR Polymorphism (rs2235749) of Prodynorphin Alters microRNA-365 Binding in Ventral Striatonigral Neurons to Influence Novelty Seeking and Positive Reward Traits.
These findings of this study suggest that, in parkinsonian animals treated with l-DOPA, the PDYN overexpression is responsible only for the development of dyskinesia.
Title: Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats.
Membrane poration by dynorphins (Prodynorphin-derived opioid peptides) may represent a mechanism of pathological signal transduction.
Title: Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction.
Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization.
Title: Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization.

Submit: New GeneRIF Correction See all GeneRIFs (37)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables opioid peptide activity	IEA Inferred from Electronic Annotation more info
enables opioid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in hippocampal mossy fiber to CA3 synapse	IEA Inferred from Electronic Annotation more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proenkephalin-B

Names: beta-neoendorphin-dynorphin; preprodynorphin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019374.3 → NP_062247.2 proenkephalin-B preproprotein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HQ68, F1M7S3

Related

ENSRNOP00000038921.3, ENSRNOT00000037576.5

Conserved Domains (1) summary

pfam01160
Location:22 → 66

Opiods_neuropep; Vertebrate endogenous opioids neuropeptide