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Ccdc68 coiled-coil domain containing 68 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291530, updated on 2-Nov-2024

Summary

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Official Symbol
Ccdc68provided by RGD
Official Full Name
coiled-coil domain containing 68provided by RGD
Primary source
RGD:1561424
See related
EnsemblRapid:ENSRNOG00000021381 AllianceGenome:RGD:1561424
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561424
Summary
Predicted to be involved in microtubule anchoring at centrosome and protein localization. Predicted to be part of centriolar subdistal appendage. Predicted to be active in centriole. Orthologous to human CCDC68 (coiled-coil domain containing 68). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 53.9), Uterus (RPKM 19.3) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccdc68 in Genome Data Viewer
Location:
18q12.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (65817232..65859529)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (63541828..63584122)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (68408812..68472323)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene transcription factor 4 Neighboring gene uncharacterized LOC134482985 Neighboring gene RAB27B, member RAS oncogene family Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68. Huang N, et al. Nat Commun, 2017 Apr 19. PMID 28422092, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in microtubule anchoring at centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule anchoring at centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of centriolar subdistal appendage ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 68
Names
CTCL tumor antigen se57-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077667.1 → NP_001071135.1  coiled-coil domain-containing protein 68

    See identical proteins and their annotated locations for NP_001071135.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127517
    UniProtKB/TrEMBL
    A0A8I5ZSZ9, A0JPN5, A6IXZ2
    Related
    ENSRNOP00000029680.4, ENSRNOT00000039702.6
    Conserved Domains (1) summary
    pfam16046
    Location:150 → 235
    FAM76; FAM76 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    65817232..65859529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277189.1 → XP_063133259.1  coiled-coil domain-containing protein 68 isoform X2

  2. XM_039096658.2 → XP_038952586.1  coiled-coil domain-containing protein 68 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0E9, A6IXZ1
    Related
    ENSRNOP00000076540.1, ENSRNOT00000110274.2
    Conserved Domains (1) summary
    COG1196
    Location:84 → 298
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_039096659.2 → XP_038952587.1  coiled-coil domain-containing protein 68 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0E9, A6IXZ1
    Related
    ENSRNOP00000103687.1, ENSRNOT00000163618.1
    Conserved Domains (1) summary
    COG1196
    Location:84 → 298
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_005496000.2 RNA Sequence

  2. XR_005495999.2 RNA Sequence

  3. XR_005496002.2 RNA Sequence

  4. XR_005496001.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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