Jag2 jagged canonical Notch ligand 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Jag2provided by RGD
Official Full Name: jagged canonical Notch ligand 2provided by RGD
Primary source: RGD:2938
See related: EnsemblRapid:ENSRNOG00000013927 AllianceGenome:RGD:2938
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Notch binding activity and growth factor activity. Involved in several processes, including male gonad development; response to hypoxia; and spermatogenesis. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human JAG2 (jagged canonical Notch ligand 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 58.6), Muscle (RPKM 50.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (137804133..137826738, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (131983059..132005665, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (137711144..137733331, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Jagged 2 inhibition attenuates hypoxia-induced mitochondrial damage and pulmonary hypertension through Sirtuin 1 signaling.
Title: Jagged 2 inhibition attenuates hypoxia-induced mitochondrial damage and pulmonary hypertension through Sirtuin 1 signaling.
Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1.
Title: β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.
The Jagged-2/Notch-1/Hes-1 signaling pathway is involved in intestinal epithelium regeneration early after I/R injury by increasing crypt epithelial cell proliferation.
Title: The jagged-2/notch-1/hes-1 pathway is involved in intestinal epithelium regeneration after intestinal ischemia-reperfusion injury.
In situ hybridization detected transcripts of Notch1 and 2 and Jagged1 and 2.
Title: Localization of Notch signaling molecules and their effect on cellular proliferation in adult rat pituitary.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Jag2 (e-PCR), detects polymorphism
- UniSTS:143637

D17S1789 (e-PCR)
- UniSTS:21272

Jag2 (e-PCR), detects polymorphism
- UniSTS:465458

UniSTS:465459 (e-PCR)
- UniSTS:465459

Jag2 (e-PCR), detects polymorphism
- UniSTS:465459

AI101320 (e-PCR)
- UniSTS:260917

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	IEA Inferred from Electronic Annotation more info
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables Notch binding	NAS Non-traceable Author Statement more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in auditory receptor cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in auditory receptor cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in auditory receptor cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in cell fate determination	NAS Non-traceable Author Statement more info	PubMed
involved_in embryonic limb morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in epithelial cell apoptotic process involved in palatal shelf morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell apoptotic process involved in palatal shelf morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in gamma-delta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in morphogenesis of embryonic epithelium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within morphogenesis of embryonic epithelium	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in respiratory system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory system process	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in thymic T cell selection	IEA Inferred from Electronic Annotation more info
involved_in thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in thymic T cell selection	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in wound healing	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: protein jagged-2

Names: jagged 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001375303.2 → NP_001362232.1 protein jagged-2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6KBW9, A6KBX0

Conserved Domains (5) summary

smart00215
Location:846 → 917

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:801 → 837

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:690 → 720

EGF; EGF-like domain

pfam01414
Location:152 → 214

DSL; Delta serrate ligand

pfam07657
Location:2 → 77

MNNL; N-terminus of Notch ligand
NM_001414899.1 → NP_001401828.1 protein jagged-2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6KBX0, E9PU23

Related

ENSRNOP00000019213.7, ENSRNOT00000019213.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

137804133..137826738 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111823.2 → XP_038967751.1 protein jagged-2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZUZ8, A6KBX0

Related

ENSRNOP00000083204.1, ENSRNOT00000100725.2

Conserved Domains (5) summary

smart00215
Location:834 → 905

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:423 → 458

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:351 → 381

EGF; EGF-like domain

pfam01414
Location:178 → 240

DSL; Delta serrate ligand

pfam07657
Location:28 → 103

MNNL; N-terminus of Notch ligand
XM_063261573.1 → XP_063117643.1 protein jagged-2 isoform X1

UniProtKB/TrEMBL

A6KBX0
XM_039111824.2 → XP_038967752.1 protein jagged-2 isoform X3

Conserved Domains (4) summary

cd00054
Location:385 → 421

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:351 → 381

EGF; EGF-like domain

pfam01414
Location:178 → 240

DSL; Delta serrate ligand

pfam07657
Location:28 → 103

MNNL; N-terminus of Notch ligand