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Jag1 jagged canonical Notch ligand 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29146, updated on 27-Nov-2024

Summary

Official Symbol
Jag1provided by RGD
Official Full Name
jagged canonical Notch ligand 1provided by RGD
Primary source
RGD:2937
See related
EnsemblRapid:ENSRNOG00000007443 AllianceGenome:RGD:2937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Predicted to be located in adherens junction and apical plasma membrane. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 122.6), Lung (RPKM 89.9) and 9 other tissues See more
Orthologs
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Genomic context

See Jag1 in Genome Data Viewer
Location:
3q36
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (144859453..144894883, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (124406783..124442220, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (130079361..130114781, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SLX4 interacting protein Neighboring gene uncharacterized LOC120101686 Neighboring gene uncharacterized LOC108350474 Neighboring gene uncharacterized LOC102547655 Neighboring gene uncharacterized LOC134486451

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 
enables Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables Notch binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell mediated immunity IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within camera-type eye development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac neural crest cell development involved in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac neural crest cell development involved in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac right ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac right ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate determination NAS
Non-traceable Author Statement
more info
PubMed 
involved_in ciliary body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ciliary body morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in distal tubule development IEA
Inferred from Electronic Annotation
more info
 
involved_in distal tubule development ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in endocardial cushion cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in inhibition of neuroepithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear auditory receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in inner ear auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear development ISO
Inferred from Sequence Orthology
more info
 
involved_in loop of Henle development IEA
Inferred from Electronic Annotation
more info
 
involved_in loop of Henle development ISO
Inferred from Sequence Orthology
more info
 
involved_in morphogenesis of an epithelial sheet IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within morphogenesis of an epithelial sheet ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in nephron development ISO
Inferred from Sequence Orthology
more info
 
involved_in nephron development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuroendocrine cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neuroendocrine cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in podocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in podocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in podocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in pulmonary artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in pulmonary artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in pulmonary valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in pulmonary valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to muramyl dipeptide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein jagged-1
Names
jagged 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019147.3NP_062020.2  protein jagged-1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P70640, Q63722
    UniProtKB/TrEMBL
    A6HQK8, G3V710
    Related
    ENSRNOP00000010638.6, ENSRNOT00000010638.9
    Conserved Domains (5) summary
    smart00215
    Location:863930
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:629665
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:748777
    EGF; EGF-like domain
    pfam01414
    Location:167229
    DSL; Delta serrate ligand
    pfam07657
    Location:32107
    MNNL; N-terminus of Notch ligand

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    144859453..144894883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)