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Trdmt1 tRNA aspartic acid methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291324, updated on 27-Nov-2024

Summary

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Official Symbol
Trdmt1provided by RGD
Official Full Name
tRNA aspartic acid methyltransferase 1provided by RGD
Primary source
RGD:1306292
See related
EnsemblRapid:ENSRNOG00000026132 AllianceGenome:RGD:1306292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dnmt2
Summary
Predicted to enable tRNA (cytidine-5-)-methyltransferase activity. Involved in response to amphetamine. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TRDMT1 (tRNA aspartic acid methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 89.6), Thymus (RPKM 88.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trdmt1 in Genome Data Viewer
Location:
17q12.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (81510740..81554036, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (76601966..76646104, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (80824652..80859585, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene Ras suppressor protein 1 Neighboring gene uncharacterized LOC134482610 Neighboring gene cubilin Neighboring gene uncharacterized LOC102550536 Neighboring gene vimentin Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-α pathway. Li Z, et al. Animal Model Exp Med, 2022 Apr. PMID 35474613, Free PMC Article
  2. Psychostimulant alters expression of DNA methyltransferase mRNA in the rat brain. Numachi Y, et al. Ann N Y Acad Sci, 2004 Oct. PMID 15542706
  3. Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. Jurkowski TP, et al. RNA, 2008 Aug. PMID 18567810, Free PMC Article
  4. The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity. Hermann A, et al. J Biol Chem, 2003 Aug 22. PMID 12794065
  5. RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis. Tuorto F, et al. Nat Struct Mol Biol, 2012 Sep. PMID 22885326

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-kappaB/MAPK-TNF-alpha pathway.
    Title: TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-α pathway.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC112666

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (cytidine-5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA (cytidine-5-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA (cytosine(38)-C(5))-methyltransferase
Names
DNA (cytosine-5)-methyltransferase-like protein 2
DNA methyltransferase 2
tRNA (cytosine-5-)-methyltransferase
NP_001026813.1
XP_063132319.1
XP_063132320.1
XP_063132321.1
XP_063132322.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031643.1 → NP_001026813.1  tRNA (cytosine(38)-C(5))-methyltransferase

    See identical proteins and their annotated locations for NP_001026813.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098700
    UniProtKB/Swiss-Prot
    Q4G073
    UniProtKB/TrEMBL
    A0A8I5YBX0, A6JM42
    Related
    ENSRNOP00000077582.1, ENSRNOT00000112273.2
    Conserved Domains (1) summary
    cd00315
    Location:4 → 391
    Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    81510740..81554036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276250.1 → XP_063132320.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X2

  2. XM_063276251.1 → XP_063132321.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X3

  3. XM_063276249.1 → XP_063132319.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X1

    Related
    ENSRNOP00000111097.1, ENSRNOT00000152886.1

  4. XM_063276252.1 → XP_063132322.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G073.1 GenPept UniProtKB/Swiss-Prot:Q4G073

Gene LinkOut

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