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Ucma upper zone of growth plate and cartilage matrix associated [ Rattus norvegicus (Norway rat) ]

Gene ID: 291312, updated on 9-Dec-2024

Summary

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Official Symbol
Ucmaprovided by RGD
Official Full Name
upper zone of growth plate and cartilage matrix associatedprovided by RGD
Primary source
RGD:1308977
See related
EnsemblRapid:ENSRNOG00000017987 AllianceGenome:RGD:1308977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GRP; RGD1308977
Summary
Predicted to enable BMP binding activity. Predicted to be involved in embryonic skeletal system development and negative regulation of SMAD protein signal transduction. Predicted to act upstream of or within negative regulation of osteoblast differentiation. Predicted to be located in cytoplasm. Predicted to be active in extracellular matrix. Orthologous to human UCMA (upper zone of growth plate and cartilage matrix associated). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 10.5), Adrenal (RPKM 8.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ucma in Genome Data Viewer
Location:
17q12.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (78203268..78212996, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (73293977..73303709, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (77252099..77262301, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene optineurin Neighboring gene uncharacterized LOC134482742 Neighboring gene minichromosome maintenance 10 replication initiation factor Neighboring gene uncharacterized LOC120097916 Neighboring gene phytanoyl-CoA 2-hydroxylase Neighboring gene selenophosphate synthetase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein. Le Jeune M, et al. Exp Cell Res, 2010 Jan 15. PMID 19819238
  2. Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling. Willems BA, et al. Sci Rep, 2018 Mar 21. PMID 29563538, Free PMC Article
  3. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. Surmann-Schmitt C, et al. J Biol Chem, 2008 Mar 14. PMID 18156182
  4. Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. Viegas CS, et al. J Biol Chem, 2008 Dec 26. PMID 18836183, Free PMC Article
  5. Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes. Tagariello A, et al. Matrix Biol, 2008 Jan. PMID 17707622

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables BMP binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in embryonic skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
unique cartilage matrix-associated protein
Names
Gla-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399350.1 → NP_001386279.1  unique cartilage matrix-associated protein precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    B9TQX4
    UniProtKB/TrEMBL
    A0A8I6A1U7
    Related
    ENSRNOP00000086256.1, ENSRNOT00000095251.2
    Conserved Domains (1) summary
    pfam17085
    Location:1 → 134
    UCMA; Unique cartilage matrix associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    78203268..78212996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106121.1: Suppressed sequence

    Description
    NM_001106121.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B9TQX4.1 GenPept UniProtKB/Swiss-Prot:B9TQX4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials