Hax1 HCLS1 associated protein X-1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hax1provided by RGD
Official Full Name: HCLS1 associated protein X-1provided by RGD
Primary source: RGD:727960
See related: EnsemblRapid:ENSRNOG00000045647 AllianceGenome:RGD:727960
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HAX-1; Hs1bp1
Summary: Enables protein domain specific binding activity. Predicted to be involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in apical plasma membrane; clathrin-coated vesicle; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in severe congenital neutropenia 3. Orthologous to human HAX1 (HCLS1 associated protein X-1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Testes (RPKM 267.9), Kidney (RPKM 246.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (177731918..177735670, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (175434242..175437926, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (189330900..189333305, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CPNE1-mediated neuronal differentiation can be inhibited by HAX1 expression in HiB5 cells.
Title: CPNE1-mediated neuronal differentiation can be inhibited by HAX1 expression in HiB5 cells.
our data indicated that HAX1 might play significant roles in pathological process of neuronal apoptosis and astrocyte proliferation during spinal cord injury
Title: HAX1 is associated with neuronal apoptosis and astrocyte proliferation after spinal cord injury.
Hax1 is significantly downregulated in cardiac cells upon endoplasmic reticulum stress induction.
Title: Endoplasmic reticulum (ER) stress triggers Hax1-dependent mitochondrial apoptotic events in cardiac cells.
these results suggested that Hax1 may participate in regulating RGC apoptosis via interacting with caspase3 and HtrA2 following ONC.
Title: Alterations in the expression of Hs1-associated protein X-1 in the rat retina after optic nerve crush.
Hax-1 is a family of anti- and proapoptotic regulators that may modulate cell survival and death through homo- or heterodimerization.
Title: Competition through dimerization between antiapoptotic and proapoptotic HS-1-associated protein X-1 (Hax-1).
Results suggest that Hax-1 may be involved in the pathophysiology of TBI and further research is needed to have a good understanding of its function and mechanism.
Title: Traumatic brain injury induces an up-regulation of Hs1-associated protein X-1 (Hax-1) in rat brain cortex.
HAX-1 is a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated muscle cells
Title: HAX-1: a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated muscle cells.
The existence of at least three protein isoforms was confirmed.
Title: Identification and expression analysis of alternative splice variants of the rat Hax-1 gene.
HAX-1 binds bile salt export protein (BSEP), cortactin, MDR1, and MDR2. HAX-1 and cortactin regulate BSEP abundance in the apical membrane of cells.
Title: Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW743138 (e-PCR)
- UniSTS:209046

RH137230 (e-PCR)
- UniSTS:219318

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables interleukin-1 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in granulocyte colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
NOT involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: HCLS1-associated protein X-1

Names: HS1 binding protein; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181627.2 → NP_853658.1 HCLS1-associated protein X-1

See identical proteins and their annotated locations for NP_853658.1

Status: PROVISIONAL

Source sequence(s)

AY291062

UniProtKB/Swiss-Prot

Q5D1N3, Q5D1N4, Q7TSE7, Q7TSE8, Q7TSE9

UniProtKB/TrEMBL

A6J6I5, B8YDD0

Related

ENSRNOP00000064877.2, ENSRNOT00000073599.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

177731918..177735670 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281443.1 → XP_063137513.1 HCLS1-associated protein X-1 isoform X10

UniProtKB/TrEMBL

B8YDD1
XM_039101872.2 → XP_038957800.1 HCLS1-associated protein X-1 isoform X9

UniProtKB/TrEMBL

A6J6I6
XM_039101868.2 → XP_038957796.1 HCLS1-associated protein X-1 isoform X4

UniProtKB/TrEMBL

B8YDD0
XM_039101871.1 → XP_038957799.1 HCLS1-associated protein X-1 isoform X8

UniProtKB/TrEMBL

B8YDD0
XM_039101867.1 → XP_038957795.1 HCLS1-associated protein X-1 isoform X3

UniProtKB/TrEMBL

B8YDD0
XM_039101870.2 → XP_038957798.1 HCLS1-associated protein X-1 isoform X7

UniProtKB/TrEMBL

A6J6I4, B8YDD0
XM_063281442.1 → XP_063137512.1 HCLS1-associated protein X-1 isoform X6

UniProtKB/TrEMBL

B8YDD0
XM_039101869.2 → XP_038957797.1 HCLS1-associated protein X-1 isoform X5

UniProtKB/TrEMBL

B8YDD0
XM_039101866.2 → XP_038957794.1 HCLS1-associated protein X-1 isoform X2

UniProtKB/TrEMBL

B8YDD0
XM_039101865.2 → XP_038957793.1 HCLS1-associated protein X-1 isoform X1

Related

ENSRNOP00000067159.3, ENSRNOT00000071253.5