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Cts7l2 cathepsin 7 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290981, updated on 14-Nov-2024

Summary

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Official Symbol
Cts7l2provided by RGD
Official Full Name
cathepsin 7 like 2provided by RGD
Primary source
RGD:1308751
See related
EnsemblRapid:ENSRNOG00000039954 AllianceGenome:RGD:1308751
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308751
Summary
Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Cts7l2 in Genome Data Viewer
Location:
17p14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (3909208..3912241)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (3903602..3907088)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (4270207..4273173)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene thioredoxin-related transmembrane protein 3, pseudogene 1 Neighboring gene testin gene Neighboring gene cathepsin L-like 3 Neighboring gene death associated protein kinase 1 Neighboring gene uncharacterized LOC100912124 Neighboring gene uncharacterized LOC103694025

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
procathepsin L
Names
cathepsin L1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    3909208..3912241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_225137.7 → XP_225137.5  procathepsin L

    See identical proteins and their annotated locations for XP_225137.5

    UniProtKB/TrEMBL
    A6KAF5, D3ZKC3
    Related
    ENSRNOP00000074913.1, ENSRNOT00000090013.3
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:114 → 329
    Peptidase_C1; Papain family cysteine protease
Nucleotide Protein Strain
Heading Accession and Version

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