U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nek1 NIMA-related kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290705, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Symbol
Nek1provided by RGD
Full Name
NIMA-related kinase 1provided by RGD
Primary source
RGD:1309375
See related
EnsemblRapid:ENSRNOG00000010418 AllianceGenome:RGD:1309375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 14-3-3 protein binding activity and protein kinase activity. Predicted to be involved in cilium assembly; protein phosphorylation; and regulation of DNA damage checkpoint. Predicted to act upstream of or within several processes, including DNA damage response; response to ionizing radiation; and spermatogenesis. Predicted to be located in centrosome; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 24; asphyxiating thoracic dystrophy; orofaciodigital syndrome II; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 79.3), Testes (RPKM 71.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nek1 in Genome Data Viewer
Location:
16p12
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (34009092..34137418, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (28998229..29125426, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (32321010..32439421, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482542 Neighboring gene SH3 domain containing ring finger 1 Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene chloride voltage-gated channel 3 Neighboring gene chromobox 3 like 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NEK1 mutations cause short-rib polydactyly syndrome type majewski. Thiel C, et al. Am J Hum Genet, 2011 Jan 7. PMID 21211617, Free PMC Article
  2. Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1. Chen Y, et al. Cell Cycle, 2009 Jan 15. PMID 19158487, Free PMC Article
  3. Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice. Upadhya P, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618398, Free PMC Article
  4. Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control. Chen Y, et al. Cell Cycle, 2008 Oct. PMID 18843199, Free PMC Article
  5. NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases. El Hokayem J, et al. J Med Genet, 2012 Apr. PMID 22499340

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein kinase Nek1
Names
NIMA (never in mitosis gene a)-related expressed kinase 1
NIMA (never in mitosis gene a)-related kinase 1
NP_001099552.2
XP_038950287.1
XP_038950288.1
XP_038950289.1
XP_038950290.1
XP_038950291.1
XP_038950292.1
XP_038950293.1
XP_038950295.1
XP_038950296.1
XP_038950297.1
XP_063131284.1
XP_063131286.1
XP_063131287.1
XP_063131288.1
XP_063131289.1
XP_063131290.1
XP_063131292.1
XP_063131293.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106082.4 → NP_001099552.2  serine/threonine-protein kinase Nek1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    D3ZB99
    Related
    ENSRNOP00000105215.1, ENSRNOT00000132983.1
    Conserved Domains (2) summary
    smart00220
    Location:4 → 258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08218
    Location:3 → 258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    34009092..34137418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275222.1 → XP_063131292.1  serine/threonine-protein kinase Nek1 isoform X8

  2. XM_063275218.1 → XP_063131288.1  serine/threonine-protein kinase Nek1 isoform X5

  3. XM_063275216.1 → XP_063131286.1  serine/threonine-protein kinase Nek1 isoform X2

  4. XM_063275214.1 → XP_063131284.1  serine/threonine-protein kinase Nek1 isoform X1

  5. XM_039094360.2 → XP_038950288.1  serine/threonine-protein kinase Nek1 isoform X1

    Conserved Domains (1) summary
    cd08218
    Location:3 → 258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

  6. XM_039094359.2 → XP_038950287.1  serine/threonine-protein kinase Nek1 isoform X1

    Conserved Domains (1) summary
    cd08218
    Location:3 → 258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

  7. XM_063275220.1 → XP_063131290.1  serine/threonine-protein kinase Nek1 isoform X7

  8. XM_063275217.1 → XP_063131287.1  serine/threonine-protein kinase Nek1 isoform X5

  9. XM_063275219.1 → XP_063131289.1  serine/threonine-protein kinase Nek1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZRX9
    Related
    ENSRNOP00000081562.1, ENSRNOT00000098175.2

  10. XM_039094361.2 → XP_038950289.1  serine/threonine-protein kinase Nek1 isoform X2

    Conserved Domains (1) summary
    cd08218
    Location:3 → 258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

  11. XM_039094362.2 → XP_038950290.1  serine/threonine-protein kinase Nek1 isoform X3

    Related
    ENSRNOP00000043277.6, ENSRNOT00000043100.7
    Conserved Domains (1) summary
    cd08218
    Location:3 → 258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

  12. XM_039094363.2 → XP_038950291.1  serine/threonine-protein kinase Nek1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K5C7
    Related
    ENSRNOP00000073376.2, ENSRNOT00000082712.3
    Conserved Domains (1) summary
    cd08218
    Location:3 → 258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

  13. XM_039094364.2 → XP_038950292.1  serine/threonine-protein kinase Nek1 isoform X8

    Related
    ENSRNOP00000108819.1, ENSRNOT00000138399.1
    Conserved Domains (1) summary
    cd08218
    Location:3 → 258
    STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

  14. XM_039094365.2 → XP_038950293.1  serine/threonine-protein kinase Nek1 isoform X9

    Conserved Domains (2) summary
    PTZ00121
    Location:120 → 526
    PTZ00121; MAEBL; Provisional
    cl21453
    Location:1 → 51
    PKc_like; Protein Kinases, catalytic domain

  15. XM_063275223.1 → XP_063131293.1  serine/threonine-protein kinase Nek1 isoform X11

  16. XM_039094367.2 → XP_038950295.1  serine/threonine-protein kinase Nek1 isoform X10

  17. XM_039094369.2 → XP_038950297.1  serine/threonine-protein kinase Nek1 isoform X13

  18. XM_039094368.2 → XP_038950296.1  serine/threonine-protein kinase Nek1 isoform X12

RNA

  1. XR_010058284.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools