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Ddx49 DEAD-box helicase 49 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290660, updated on 14-Nov-2024

Summary

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Official Symbol
Ddx49provided by RGD
Official Full Name
DEAD-box helicase 49provided by RGD
Primary source
RGD:1311124
See related
EnsemblRapid:ENSRNOG00000022368 AllianceGenome:RGD:1311124
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be involved in positive regulation of cell growth; rRNA processing; and regulation of rRNA stability. Predicted to be active in nucleus. Orthologous to human DDX49 (DEAD-box helicase 49). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 96.2), Adrenal (RPKM 96.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ddx49 in Genome Data Viewer
Location:
16p14
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19159353..19167003)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19125388..19133042)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20873585..20881312)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene UPF1, RNA helicase and ATPase Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene COPI coat complex subunit epsilon Neighboring gene homer scaffold protein 3 Neighboring gene SURP and G patch domain containing 2 Neighboring gene transmembrane protein 60-like Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA. Awasthi S, et al. Nucleic Acids Res, 2018 Jul 6. PMID 29618122, Free PMC Article
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of rRNA stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX49
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
NP_001108495.1
XP_063131257.1
XP_063131258.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115023.1 → NP_001108495.1  probable ATP-dependent RNA helicase DDX49

    See identical proteins and their annotated locations for NP_001108495.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158855
    UniProtKB/TrEMBL
    A0A8I6A3R8, B0BNK0
    Related
    ENSRNOP00000004891.5, ENSRNOT00000004891.8
    Conserved Domains (4) summary
    PTZ00424
    Location:4 → 382
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:218 → 351
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:4 → 206
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    cl19511
    Location:363 → 454
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    19159353..19167003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275187.1 → XP_063131257.1  probable ATP-dependent RNA helicase DDX49 isoform X1

    UniProtKB/TrEMBL
    E9PTF0

  2. XM_063275188.1 → XP_063131258.1  probable ATP-dependent RNA helicase DDX49 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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