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Pgpep1 pyroglutamyl-peptidase I [ Rattus norvegicus (Norway rat) ]

Gene ID: 290648, updated on 9-Dec-2024

Summary

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Official Symbol
Pgpep1provided by RGD
Official Full Name
pyroglutamyl-peptidase Iprovided by RGD
Primary source
RGD:1303133
See related
EnsemblRapid:ENSRNOG00000019657 AllianceGenome:RGD:1303133
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PAPI
Summary
Enables peptidase activity. Involved in protein catabolic process. Predicted to be located in cytosol. Orthologous to human PGPEP1 (pyroglutamyl-peptidase I). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 1611.9), Liver (RPKM 468.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pgpep1 in Genome Data Viewer
Location:
16p14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18804408..18817466)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18770563..18782968)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20521989..20531254)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene JunD proto-oncogene, AP-1 transcription factor subunit Neighboring gene uncharacterized LOC134482471 Neighboring gene LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene Mk1 protein Neighboring gene growth differentiation factor 15 Neighboring gene leucine rich repeat containing 25 Neighboring gene single stranded DNA binding protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hydrolysis of synthetic substrate, L-pyroglutamyl p-nitroanilide is catalyzed solely by pyroglutamyl aminopeptidase I in rat liver cytosol. Abe K, et al. Biol Pharm Bull, 2003 Nov. PMID 14600395
  2. Serum pyrrolidone carboxypeptidase activity in N-methyl-nitrosourea induced rat breast cancer. Carrera MP, et al. Horm Metab Res, 2003 Aug. PMID 12953169
  3. Effect of the disruption of body fluid balance on pyroglutamyl aminopeptidase (Type-1) in rat brain structures. Irazusta J, et al. Neuropeptides, 2002 Oct. PMID 12450739
  4. Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland. Konishi H, et al. Biochem Biophys Res Commun, 2011 Apr 1. PMID 21329657
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAP-I and PAP-II expression was induced by the decreased dopamine levels in the intermediate lobe of the pituitary under continuous stress.
    Title: Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland.
  2. Significant correlation between Pcp activity and the number and size of tumours and the body weight of the animals. Decreased Pcp may reflect increase in circulating GnRH leading to increase in gonadal steroid hormones.
    Title: Serum pyrrolidone carboxypeptidase activity in N-methyl-nitrosourea induced rat breast cancer.
  3. Pyroglutamyl aminopeptidase Type-1 shows differentiated activity in various parts of the brain under varied conditions of hydration in rats.
    Title: Effect of the disruption of body fluid balance on pyroglutamyl aminopeptidase (Type-1) in rat brain structures.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyroglutamyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyroglutamyl-peptidase 1
Names
5-oxoprolyl-peptidase
PAP-I
PGP-I
pyroglutamyl aminopeptidase I
pyrrolidone-carboxylate peptidase
NP_973717.1
XP_038950248.1
XP_063131229.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201988.2 → NP_973717.1  pyroglutamyl-peptidase 1

    See identical proteins and their annotated locations for NP_973717.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098645
    UniProtKB/Swiss-Prot
    Q76IC5
    UniProtKB/TrEMBL
    A0A8I6B2L0, A6KA15
    Related
    ENSRNOP00000026601.3, ENSRNOT00000026601.5
    Conserved Domains (1) summary
    cd00501
    Location:6 → 199
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18804408..18817466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094320.2 → XP_038950248.1  pyroglutamyl-peptidase 1 isoform X1

    Conserved Domains (1) summary
    cl00237
    Location:1 → 122
    Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

  2. XM_063275159.1 → XP_063131229.1  pyroglutamyl-peptidase 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76IC5.1 GenPept UniProtKB/Swiss-Prot:Q76IC5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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