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Spcs1 signal peptidase complex subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290555, updated on 27-Nov-2024

Summary

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Official Symbol
Spcs1provided by RGD
Official Full Name
signal peptidase complex subunit 1provided by RGD
Primary source
RGD:1309125
See related
AllianceGenome:RGD:1309125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309125
Summary
Predicted to enable ribosome binding activity. Predicted to be involved in several processes, including protein targeting to ER; signal peptide processing; and viral protein processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 623.3), Kidney (RPKM 536.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spcs1 in Genome Data Viewer
Location:
16p16
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6196653..6198221, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6190208..6191776, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7080389..7081957, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene inter-alpha trypsin inhibitor, heavy chain 3 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1 Neighboring gene NIMA-related kinase 4 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene small nucleolar RNA SNORD19B Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene G protein nucleolar 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Host Factor SPCS1 Regulates the Replication of Japanese Encephalitis Virus through Interactions with Transmembrane Domains of NS2B. Ma L, et al. J Virol, 2018 Jun 15. PMID 29593046, Free PMC Article
  2. Signal peptidase complex subunit 1 participates in the assembly of hepatitis C virus through an interaction with E2 and NS2. Suzuki R, et al. PLoS Pathog, 2013. PMID 24009510, Free PMC Article
  3. Membrane topology and biogenesis of eukaryotic signal peptidase. Shelness GS, et al. J Biol Chem, 1993 Mar 5. PMID 8444896
  4. Purification of microsomal signal peptidase as a complex. Evans EA, et al. Proc Natl Acad Sci U S A, 1986 Feb. PMID 3511473, Free PMC Article
  5. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188913

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
  
involved_in viral protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in virion assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal peptidase complex subunit 1
Names
signal peptidase complex subunit 1 homolog
NP_001124478.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131006.1 → NP_001124478.1  signal peptidase complex subunit 1

    Status: VALIDATED

    Source sequence(s)
    CF976587, CV795143
    Conserved Domains (1) summary
    pfam06645
    Location:12 → 81
    SPC12; Microsomal signal peptidase 12 kDa subunit (SPC12)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    6196653..6198221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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