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Ggact gamma-glutamylamine cyclotransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 290500, updated on 4-Jan-2025

Summary

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Official Symbol
Ggactprovided by RGD
Official Full Name
gamma-glutamylamine cyclotransferaseprovided by RGD
Primary source
RGD:1304748
See related
EnsemblRapid:ENSRNOG00000027040 AllianceGenome:RGD:1304748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
A2ld1
Summary
Predicted to enable gamma-glutamylaminecyclotransferase activity. Predicted to be involved in modified amino acid catabolic process. Predicted to be active in cytosol. Orthologous to human GGACT (gamma-glutamylamine cyclotransferase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 64.3), Adrenal (RPKM 58.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ggact in Genome Data Viewer
Location:
15q25
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (106375924..106406649, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (99969246..99998343, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (109307683..109336779, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L24, pseudogene 6 Neighboring gene propionyl-CoA carboxylase subunit alpha Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 4 Neighboring gene small nucleolar RNA SNORA44

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism. Oakley AJ, et al. J Biol Chem, 2010 Mar 26. PMID 20110353, Free PMC Article
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112665

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gamma-glutamylaminecyclotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables gamma-glutamylaminecyclotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables gamma-glutamylaminecyclotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in modified amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in modified amino acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in modified amino acid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-glutamylaminecyclotransferase
Names
AIG2-like domain 1
AIG2-like domain-containing protein 1
NP_001020805.2
NP_001296987.1
XP_006252574.1
XP_006252575.1
XP_006252582.1
XP_006252583.1
XP_006252584.1
XP_038949130.1
XP_038949131.1
XP_038949133.1
XP_063130246.1
XP_063130247.1
XP_063130248.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025634.2 → NP_001020805.2  gamma-glutamylaminecyclotransferase

    See identical proteins and their annotated locations for NP_001020805.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A6HUM7
    Conserved Domains (1) summary
    pfam06094
    Location:19 → 149
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

  2. NM_001310058.1 → NP_001296987.1  gamma-glutamylaminecyclotransferase

    See identical proteins and their annotated locations for NP_001296987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A6HUM7
    Conserved Domains (1) summary
    pfam06094
    Location:19 → 149
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    106375924..106406649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274178.1 → XP_063130248.1  gamma-glutamylaminecyclotransferase isoform X2

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A6HUM7

  2. XM_006252520.5 → XP_006252582.1  gamma-glutamylaminecyclotransferase isoform X2

    See identical proteins and their annotated locations for XP_006252582.1

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A6HUM7
    Conserved Domains (1) summary
    pfam06094
    Location:19 → 149
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

  3. XM_063274176.1 → XP_063130246.1  gamma-glutamylaminecyclotransferase isoform X1

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A0A8L2PXS0
    Related
    ENSRNOP00000000118.3, ENSRNOT00000019158.7

  4. XM_006252512.5 → XP_006252574.1  gamma-glutamylaminecyclotransferase isoform X1

    See identical proteins and their annotated locations for XP_006252574.1

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A0A8L2PXS0
    Conserved Domains (1) summary
    pfam06094
    Location:33 → 144
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

  5. XM_039093202.2 → XP_038949130.1  gamma-glutamylaminecyclotransferase isoform X2

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A6HUM7
    Conserved Domains (1) summary
    pfam06094
    Location:19 → 149
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

  6. XM_006252521.4 → XP_006252583.1  gamma-glutamylaminecyclotransferase isoform X2

    See identical proteins and their annotated locations for XP_006252583.1

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A6HUM7
    Conserved Domains (1) summary
    pfam06094
    Location:19 → 149
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

  7. XM_006252522.5 → XP_006252584.1  gamma-glutamylaminecyclotransferase isoform X2

    See identical proteins and their annotated locations for XP_006252584.1

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A6HUM7
    Conserved Domains (1) summary
    pfam06094
    Location:19 → 149
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

  8. XM_006252513.4 → XP_006252575.1  gamma-glutamylaminecyclotransferase isoform X1

    See identical proteins and their annotated locations for XP_006252575.1

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A0A8L2PXS0
    Conserved Domains (1) summary
    pfam06094
    Location:33 → 144
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

  9. XM_039093203.2 → XP_038949131.1  gamma-glutamylaminecyclotransferase isoform X2

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A6HUM7
    Conserved Domains (1) summary
    pfam06094
    Location:19 → 149
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

  10. XM_039093205.2 → XP_038949133.1  gamma-glutamylaminecyclotransferase isoform X2

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A6HUM7
    Conserved Domains (1) summary
    pfam06094
    Location:19 → 149
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

  11. XM_063274177.1 → XP_063130247.1  gamma-glutamylaminecyclotransferase isoform X1

    UniProtKB/Swiss-Prot
    Q4KM86
    UniProtKB/TrEMBL
    A0A8L2PXS0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KM86.1 GenPept UniProtKB/Swiss-Prot:Q4KM86

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