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Pbk PDZ binding kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 290326, updated on 27-Nov-2024

Summary

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Official Symbol
Pbkprovided by RGD
Official Full Name
PDZ binding kinaseprovided by RGD
Primary source
RGD:1309565
See related
EnsemblRapid:ENSRNOG00000015308 AllianceGenome:RGD:1309565
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in stress-activated MAPK cascade. Predicted to act upstream of or within several processes, including cellular response to UV; negative regulation of protein metabolic process; and negative regulation of stress-activated MAPK cascade. Predicted to be located in nucleus. Orthologous to human PBK (PDZ binding kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 96.0), Thymus (RPKM 81.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pbk in Genome Data Viewer
Location:
15p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44198506..44209572)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40022873..40034014)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (42489253..42500377)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097185 Neighboring gene scavenger receptor class A, member 5 Neighboring gene uncharacterized LOC108352941 Neighboring gene uncharacterized LOC134482136 Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene coiled-coil domain containing 25 Neighboring gene NOP53 ribosome biogenesis factor, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activation of T-LAK-cell-originated protein kinase-mediated antioxidation protects against focal cerebral ischemia-reperfusion injury. Zhao H, et al. FEBS J, 2014 Oct. PMID 25065601
  2. Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins. Rizkallah R, et al. Oncotarget, 2015 Jan 30. PMID 25575812, Free PMC Article
  3. T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway. Li S, et al. J Biol Chem, 2011 Aug 26. PMID 21715333, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOPK confers neuroprotection against focal cerebral ischemia-reperfusion injury by antioxidative function.
    Title: Activation of T-LAK-cell-originated protein kinase-mediated antioxidation protects against focal cerebral ischemia-reperfusion injury.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lymphokine-activated killer T-cell-originated protein kinase
NP_001073406.1
XP_006252165.1
XP_006252167.1
XP_006252168.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079937.1 → NP_001073406.1  lymphokine-activated killer T-cell-originated protein kinase

    See identical proteins and their annotated locations for NP_001073406.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129099
    UniProtKB/TrEMBL
    A1L1J7, D4A9B1
    Conserved Domains (1) summary
    cd14001
    Location:32 → 319
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    44198506..44209572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252103.5 → XP_006252165.1  lymphokine-activated killer T-cell-originated protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006252165.1

    UniProtKB/TrEMBL
    A1L1J7, D4A9B1
    Related
    ENSRNOP00000100563.1, ENSRNOT00000132475.1
    Conserved Domains (1) summary
    cd14001
    Location:32 → 319
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

  2. XM_006252106.5 → XP_006252168.1  lymphokine-activated killer T-cell-originated protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006252168.1

    UniProtKB/TrEMBL
    A1L1J7, D4A9B1
    Related
    ENSRNOP00000061382.2, ENSRNOT00000064306.5
    Conserved Domains (1) summary
    cd14001
    Location:32 → 319
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

  3. XM_006252105.3 → XP_006252167.1  lymphokine-activated killer T-cell-originated protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006252167.1

    UniProtKB/TrEMBL
    A1L1J7, D4A9B1
    Conserved Domains (1) summary
    cd14001
    Location:32 → 319
    PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase
Nucleotide Protein Strain
Heading Accession and Version

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