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Dhrs1 dehydrogenase/reductase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290234, updated on 27-Nov-2024

Summary

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Official Symbol
Dhrs1provided by RGD
Official Full Name
dehydrogenase/reductase 1provided by RGD
Primary source
RGD:1359172
See related
EnsemblRapid:ENSRNOG00000020264 AllianceGenome:RGD:1359172
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable carbonyl reductase (NADPH) activity. Predicted to be located in endoplasmic reticulum. Orthologous to human DHRS1 (dehydrogenase/reductase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 89.0), Kidney (RPKM 79.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dhrs1 in Genome Data Viewer
Location:
15p13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33206449..33213776, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29236522..29243807, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34424017..34431302, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene Rab geranylgeranyltransferase subunit alpha Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 2 Neighboring gene NOP9 nucleolar protein Neighboring gene cell death-inducing DFFA-like effector b Neighboring gene leukotriene B4 receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain. Wu Q, et al. Mol Biol Rep, 2001. PMID 12153138
  2. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94370

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbonyl reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 1
Names
dehydrogenase/reductase (SDR family) member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007621.1 → NP_001007622.1  dehydrogenase/reductase SDR family member 1

    See identical proteins and their annotated locations for NP_001007622.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079263
    UniProtKB/TrEMBL
    A0A8I5ZRF1, A0A8I5ZVF5, F7F1T8, Q6AXY8
    Related
    ENSRNOP00000027511.3, ENSRNOT00000027511.7
    Conserved Domains (2) summary
    cd09763
    Location:5 → 271
    DHRS1-like_SDR_c; human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs
    PRK08303
    Location:1 → 271
    PRK08303; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    33206449..33213776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274127.1 → XP_063130197.1  dehydrogenase/reductase SDR family member 1 isoform X1

  2. XM_063274128.1 → XP_063130198.1  dehydrogenase/reductase SDR family member 1 isoform X2

  3. XM_063274130.1 → XP_063130200.1  dehydrogenase/reductase SDR family member 1 isoform X5

  4. XM_063274129.1 → XP_063130199.1  dehydrogenase/reductase SDR family member 1 isoform X4

  5. XM_039093133.2 → XP_038949061.1  dehydrogenase/reductase SDR family member 1 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:5 → 200
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  6. XM_039093132.2 → XP_038949060.1  dehydrogenase/reductase SDR family member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRF1, A0A8I5ZVF5
    Conserved Domains (1) summary
    cl21454
    Location:5 → 222
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  7. XM_039093134.2 → XP_038949062.1  dehydrogenase/reductase SDR family member 1 isoform X3

    Conserved Domains (1) summary
    cl21454
    Location:5 → 170
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version

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