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Gpr137b G protein-coupled receptor 137B [ Rattus norvegicus (Norway rat) ]

Gene ID: 289287, updated on 27-Nov-2024

Summary

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Official Symbol
Gpr137bprovided by RGD
Official Full Name
G protein-coupled receptor 137Bprovided by RGD
Primary source
RGD:1307342
See related
EnsemblRapid:ENSRNOG00000002480 AllianceGenome:RGD:1307342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tm7sf1
Summary
Predicted to be involved in several processes, including negative regulation of bone resorption; positive regulation of TORC1 signaling; and positive regulation of protein localization to lysosome. Predicted to be active in lysosomal membrane. Orthologous to human GPR137B (G protein-coupled receptor 137B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 272.7), Kidney (RPKM 268.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr137b in Genome Data Viewer
Location:
17q12.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (92987792..93026003, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (86003635..86041841, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (90670852..90709003)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene EDAR associated via death domain Neighboring gene endoplasmic reticulum oxidoreductase 1 beta Neighboring gene nidogen 1 Neighboring gene uncharacterized LOC134482624

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization. Islam Z, et al. Biochem Biophys Res Commun, 2019 Feb 12. PMID 30595385
  2. A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish. Urso K, et al. Bone, 2019 Oct. PMID 31173907, Free PMC Article
  3. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, et al. Nat Cell Biol, 2019 May. PMID 31036939, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integral membrane protein GPR137B
Names
transmembrane 7 superfamily member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399407.1 → NP_001386336.1  integral membrane protein GPR137B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8I6G770
    Related
    ENSRNOP00000100489.1, ENSRNOT00000171810.1
    Conserved Domains (1) summary
    cd21476
    Location:20 → 339
    7tm_GPR137B; Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001399408.1 → NP_001386337.1  integral membrane protein GPR137B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A0G2K234
    Related
    ENSRNOP00000072087.2, ENSRNOT00000081530.3
    Conserved Domains (1) summary
    cd21476
    Location:20 → 339
    7tm_GPR137B; Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    92987792..93026003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095436.2 → XP_038951364.1  integral membrane protein GPR137B isoform X1

    UniProtKB/TrEMBL
    D3ZK26
    Conserved Domains (2) summary
    cd21464
    Location:31 → 53
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:20 → 295
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105978.1: Suppressed sequence

    Description
    NM_001105978.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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