Cfhr1 complement factor H-related 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfhr1provided by RGD
Official Full Name: complement factor H-related 1provided by RGD
Primary source: RGD:1310510
See related: EnsemblRapid:ENSRNOG00000042901 AllianceGenome:RGD:1310510
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cfhl1
Summary: Predicted to enable complement component C3b binding activity and identical protein binding activity. Predicted to be involved in complement activation and cytolysis by host of symbiont cells. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in acute myeloid leukemia; age related macular degeneration 1; atypical hemolytic-uremic syndrome; and multiple myeloma. Orthologous to several human genes including CFHR1 (complement factor H related 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 2152.1) See more
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Genomic context

Location:: 13q13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (53946298..53961282, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (51395583..51410571, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (56862666..56877650, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH127927 (e-PCR)
- UniSTS:211237

RH127572 (e-PCR)
- UniSTS:210882

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables complement component C3b binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in complement activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytolysis by host of symbiont cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement factor H-related protein 1

Names: complement component factor h-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044227.2 → NP_001037692.1 complement factor H-related protein 1 precursor

See identical proteins and their annotated locations for NP_001037692.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F7ESI5, Q5I0M3

Related

ENSRNOP00000017195.6, ENSRNOT00000017195.9

Conserved Domains (1) summary

cd00033
Location:154 → 208

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system