U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dennd1b DENN domain containing 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 289051, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Dennd1bprovided by RGD
Official Full Name
DENN domain containing 1Bprovided by RGD
Primary source
RGD:1308441
See related
EnsemblRapid:ENSRNOG00000011063 AllianceGenome:RGD:1308441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam31b
Summary
Predicted to enable guanyl-nucleotide exchange factor activity; phosphatidylinositol phosphate binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including endocytic recycling; positive regulation of GTPase activity; and positive regulation of immune response. Predicted to be located in clathrin-coated vesicle. Predicted to be active in cytosol and nuclear speck. Orthologous to human DENND1B (DENN domain containing 1B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 210.8), Heart (RPKM 124.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dennd1b in Genome Data Viewer
Location:
13q13
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (53096717..53324372)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (50545324..50772922)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (56015813..56242041)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481501 Neighboring gene similar to human chromosome 1 open reading frame 53 Neighboring gene uncharacterized LOC120096262 Neighboring gene uncharacterized LOC120096263 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene crumbs cell polarity complex component 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease. Yang CW, et al. Cell, 2016 Jan 14. PMID 26774822
  2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of immune response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DENN domain-containing protein 1B
Names
DENN/MADD domain containing 1B
family with sequence similarity 31, member B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430770.1 → NP_001417699.1  DENN domain-containing protein 1B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6AN53, F1M3B0

  2. NM_001430771.1 → NP_001417700.1  DENN domain-containing protein 1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6AN53

  3. NM_001430772.1 → NP_001417701.1  DENN domain-containing protein 1B isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6AN53

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    53096717..53324372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272684.1 → XP_063128754.1  DENN domain-containing protein 1B isoform X5

    UniProtKB/TrEMBL
    A0A8I6G654

  2. XM_039091333.2 → XP_038947261.1  DENN domain-containing protein 1B isoform X6

    UniProtKB/TrEMBL
    A0A8I6AN53
    Conserved Domains (2) summary
    smart00801
    Location:248 → 313
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:19 → 216
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

  3. XM_003751245.4 → XP_003751293.1  DENN domain-containing protein 1B isoform X3

    Related
    ENSRNOP00000037059.6, ENSRNOT00000035129.7
    Conserved Domains (3) summary
    smart00801
    Location:323 → 388
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:94 → 291
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 89
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  4. XM_003751244.4 → XP_003751292.1  DENN domain-containing protein 1B isoform X4

    Related
    ENSRNOP00000043081.7, ENSRNOT00000043907.8
    Conserved Domains (3) summary
    smart00801
    Location:303 → 368
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:94 → 271
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 89
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  5. XM_008769580.3 → XP_008767802.1  DENN domain-containing protein 1B isoform X5

    See identical proteins and their annotated locations for XP_008767802.1

    UniProtKB/TrEMBL
    A0A8I6G654
    Related
    ENSRNOP00000080096.1, ENSRNOT00000094144.2
    Conserved Domains (2) summary
    smart00801
    Location:245 → 310
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:20 → 213
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

  6. XM_063272683.1 → XP_063128753.1  DENN domain-containing protein 1B isoform X2

    UniProtKB/TrEMBL
    A0A8I6AN53, D3Z8F6
    Related
    ENSRNOP00000099618.1, ENSRNOT00000136226.1

  7. XM_063272682.1 → XP_063128752.1  DENN domain-containing protein 1B isoform X1

    Related
    ENSRNOP00000082359.2, ENSRNOT00000112392.2

  8. XM_063272685.1 → XP_063128755.1  DENN domain-containing protein 1B isoform X5

    UniProtKB/TrEMBL
    A0A8I6G654

  9. XM_039091335.2 → XP_038947263.1  DENN domain-containing protein 1B isoform X7

    Conserved Domains (2) summary
    smart00801
    Location:248 → 313
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:19 → 216
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

  10. XM_039091336.1 → XP_038947264.1  DENN domain-containing protein 1B isoform X8

    Conserved Domains (2) summary
    smart00801
    Location:85 → 150
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    cl11519
    Location:1 → 53
    DENN; DENN (AEX-3) domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105954.1: Suppressed sequence

    Description
    NM_001105954.1: This RefSeq was suppressed temporarily because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools