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Rasa4 RAS p21 protein activator 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288589, updated on 27-Nov-2024

Summary

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Official Symbol
Rasa4provided by RGD
Official Full Name
RAS p21 protein activator 4provided by RGD
Primary source
RGD:1565457
See related
EnsemblRapid:ENSRNOG00000001431 AllianceGenome:RGD:1565457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Capri; RGD1565457
Summary
Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to be involved in cellular response to calcium ion; intracellular signal transduction; and negative regulation of Ras protein signal transduction. Orthologous to several human genes including RASA4B (RAS p21 protein activator 4B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 105.7), Thymus (RPKM 42.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rasa4 in Genome Data Viewer
Location:
12q12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26189416..26216801, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (20552805..20580177, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23596989..23624386, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene alkB homolog 4, lysine demethylase Neighboring gene leucine-rich repeats and WD repeat domain containing 1 Neighboring gene RNA polymerase II subunit J Neighboring gene uncharacterized LOC134481278 Neighboring gene uroplakin 3B like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The plasma membrane shuttling of CAPRI is related to regulation of mast cell activation. Nakamura R, et al. Biochem Biophys Res Commun, 2006 Aug 18. PMID 16815298
  2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein 4; ras GTPase-activating protein 4B
Names
calcium-promoted RAS inactivator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432268.1 → NP_001419197.1  ras GTPase-activating protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J086, D3ZQH9

  2. NM_001432269.1 → NP_001419198.1  ras GTPase-activating protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J088

  3. NM_001432270.1 → NP_001419199.1  ras GTPase-activating protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J088

  4. NM_001432271.1 → NP_001419200.1  ras GTPase-activating protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    26189416..26216801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002727953.6 → XP_002727999.1  ras GTPase-activating protein 4B isoform X1

    Related
    ENSRNOP00000001943.6, ENSRNOT00000001943.10
    Conserved Domains (7) summary
    cd04054
    Location:6 → 126
    C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
    smart00323
    Location:245 → 604
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13372
    Location:541 → 680
    PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
    pfam00169
    Location:566 → 671
    PH; PH domain
    pfam00779
    Location:680 → 708
    BTK; BTK motif
    cl02569
    Location:264 → 549
    RasGAP; Ras GTPase Activating Domain
    cl14603
    Location:134 → 256
    C2; C2 domain

  2. XM_039090070.2 → XP_038945998.1  ras GTPase-activating protein 4B isoform X2

    Conserved Domains (3) summary
    cd13372
    Location:191 → 330
    PH_CAPRI; Ca2+ promoted Ras inactivator pleckstrin homology (PH) domain
    pfam00779
    Location:330 → 358
    BTK; BTK motif
    cl02569
    Location:1 → 199
    RasGAP; Ras GTPase Activating Domain
Nucleotide Protein Strain
Heading Accession and Version

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