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Akap17a A-kinase anchoring protein 17A [ Rattus norvegicus (Norway rat) ]

Gene ID: 288526, updated on 4-Jan-2025

Summary

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Official Symbol
Akap17aprovided by RGD
Official Full Name
A-kinase anchoring protein 17Aprovided by RGD
Primary source
RGD:1564640
See related
EnsemblRapid:ENSRNOG00000028211 AllianceGenome:RGD:1564640
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase A binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be active in cytosol and nuclear speck. Orthologous to human AKAP17A (A-kinase anchoring protein 17A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 73.3), Spleen (RPKM 56.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Akap17a in Genome Data Viewer
Location:
12q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (21424202..21428308, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (16310427..16315166, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (18527116..18531780, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase X-linked Neighboring gene acetylserotonin O-methyltransferase Neighboring gene acetylserotonin O-methyltransferase-like Neighboring gene interleukin 3 receptor subunit alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments. Jarnaess E, et al. J Biol Chem, 2009 Dec 11. PMID 19840947, Free PMC Article
  2. XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265. Mangs AH, et al. Nucleic Acids Res, 2006. PMID 16982639, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 17A
Names
A kinase (PRKA) anchor protein 17A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127246.2 → NP_001120718.2  A-kinase anchor protein 17A

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    B2RYB9, F1MAF2
    Related
    ENSRNOP00000032594.4, ENSRNOT00000037829.6
    Conserved Domains (2) summary
    pfam15709
    Location:282 → 445
    DUF4670; Domain of unknown function (DUF4670)
    cl17169
    Location:147 → 278
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    21424202..21428308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248999.4 → XP_006249061.1  A-kinase anchor protein 17A isoform X1

    See identical proteins and their annotated locations for XP_006249061.1

    UniProtKB/TrEMBL
    B2RYB9, F1MAF2
    Conserved Domains (2) summary
    pfam15709
    Location:282 → 445
    DUF4670; Domain of unknown function (DUF4670)
    cl17169
    Location:147 → 278
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_006249000.4 → XP_006249062.1  A-kinase anchor protein 17A isoform X1

    See identical proteins and their annotated locations for XP_006249062.1

    UniProtKB/TrEMBL
    B2RYB9, F1MAF2
    Conserved Domains (2) summary
    pfam15709
    Location:282 → 445
    DUF4670; Domain of unknown function (DUF4670)
    cl17169
    Location:147 → 278
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_006248998.4 → XP_006249060.1  A-kinase anchor protein 17A isoform X1

    See identical proteins and their annotated locations for XP_006249060.1

    UniProtKB/TrEMBL
    B2RYB9, F1MAF2
    Conserved Domains (2) summary
    pfam15709
    Location:282 → 445
    DUF4670; Domain of unknown function (DUF4670)
    cl17169
    Location:147 → 278
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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