U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Get4 guided entry of tail-anchored proteins factor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288518, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Get4provided by RGD
Official Full Name
guided entry of tail-anchored proteins factor 4provided by RGD
Primary source
RGD:1311660
See related
EnsemblRapid:ENSRNOG00000001299 AllianceGenome:RGD:1311660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cee; RGD1311660
Summary
Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in several processes, including cytoplasmic sequestering of protein; establishment of protein localization to membrane; and proteolysis involved in protein catabolic process. Predicted to be located in chromosome; cytoplasm; and nuclear lumen. Predicted to be part of BAT3 complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GET4 (guided entry of tail-anchored proteins factor 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 48.3), Heart (RPKM 32.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Get4 in Genome Data Viewer
Location:
12q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20490861..20508096, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15377009..15394238, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17469112..17486709, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly factor COX19 Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene uncharacterized LOC102547493 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene dynein, axonemal, assembly factor 5 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35. Mock JY, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29042515, Free PMC Article
  2. A ribosome-associating factor chaperones tail-anchored membrane proteins. Mariappan M, et al. Nature, 2010 Aug 26. PMID 20676083, Free PMC Article
  3. Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. Mock JY, et al. Proc Natl Acad Sci U S A, 2015 Jan 6. PMID 25535373, Free PMC Article
  4. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Wang Q, et al. Mol Cell, 2011 Jun 24. PMID 21636303, Free PMC Article
  5. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic sequestering of protein ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of unfolded protein ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein targeting to endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of BAT3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BAT3 complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Golgi to ER traffic protein 4 homolog
Names
conserved edge expressed protein
golgi to ER traffic protein 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163320.1 → NP_001156792.1  Golgi to ER traffic protein 4 homolog

    See identical proteins and their annotated locations for NP_001156792.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6A965, A6K1X1, F1LXF5
    Related
    ENSRNOP00000088319.1, ENSRNOT00000108209.2
    Conserved Domains (1) summary
    pfam04190
    Location:59 → 295
    DUF410; Protein of unknown function (DUF410)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    20490861..20508096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248927.5 → XP_006248989.1  Golgi to ER traffic protein 4 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6A965
    Conserved Domains (1) summary
    pfam04190
    Location:59 → 294
    DUF410; Protein of unknown function (DUF410)

RNA

  1. XR_010056369.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools