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Recql5 RecQ like helicase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287834, updated on 27-Nov-2024

Summary

Official Symbol
Recql5provided by RGD
Official Full Name
RecQ like helicase 5provided by RGD
Primary source
RGD:1310823
See related
EnsemblRapid:ENSRNOG00000005107 AllianceGenome:RGD:1310823
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RecQ5
Summary
Predicted to enable DNA helicase activity; RNA polymerase II complex binding activity; and identical protein binding activity. Predicted to be involved in DNA metabolic process; chromosome separation; and negative regulation of transcription elongation by RNA polymerase II. Predicted to act upstream of or within several processes, including cellular response to camptothecin; negative regulation of double-strand break repair via homologous recombination; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription preinitiation complex. Predicted to be active in cytoplasm and replication fork. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 69.3), Spleen (RPKM 62.0) and 9 other tissues See more
Orthologs
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Genomic context

See Recql5 in Genome Data Viewer
Location:
10q32.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101625477..101664582, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101126544..101165739, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104443735..104482889, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene LLGL scribble cell polarity complex component 2 Neighboring gene myosin XVB Neighboring gene small integral membrane protein 5 Neighboring gene endoregulin Neighboring gene SAP30 binding protein Neighboring gene ribosomal protein S18-like 1 Neighboring gene integrin subunit beta 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
 
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables forked DNA-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables four-way junction helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to camptothecin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome separation ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome separation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription elongation by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within replication-born double-strand break repair via sister chromatid exchange ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in replication fork ISO
Inferred from Sequence Orthology
more info
 
part_of transcription preinitiation complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-dependent DNA helicase Q5
Names
DNA 3'-5' helicase RecQ5
DNA helicase, RecQ-like type 5
RecQ helicase-like 5
RecQ protein-like 5
NP_001099323.1
XP_017452650.1
XP_038941602.1
XP_038941603.1
XP_038941604.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105853.1NP_001099323.1  ATP-dependent DNA helicase Q5

    See identical proteins and their annotated locations for NP_001099323.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/Swiss-Prot
    D4ACP5
    UniProtKB/TrEMBL
    A0A8I6ALQ3
    Related
    ENSRNOP00000007246.4, ENSRNOT00000007246.7
    Conserved Domains (5) summary
    smart00487
    Location:22229
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:258363
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:31201
    DEAD; DEAD/DEAH box helicase
    pfam06959
    Location:626816
    RecQ5; RecQ helicase protein-like 5 (RecQ5)
    pfam16124
    Location:368435
    RecQ_Zn_bind; RecQ zinc-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    101625477..101664582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085674.2XP_038941602.1  ATP-dependent DNA helicase Q5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ALQ3
    Related
    ENSRNOP00000107175.1, ENSRNOT00000143862.1
    Conserved Domains (2) summary
    COG0514
    Location:15439
    RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
    pfam06959
    Location:600771
    RecQ5; RecQ helicase protein-like 5 (RecQ5)
  2. XM_017597161.3XP_017452650.1  ATP-dependent DNA helicase Q5 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ALQ3
    Related
    ENSRNOP00000106280.1, ENSRNOT00000144127.1
  3. XM_039085675.2XP_038941603.1  ATP-dependent DNA helicase Q5 isoform X3

    Conserved Domains (2) summary
    pfam06959
    Location:223413
    RecQ5; RecQ helicase protein-like 5 (RecQ5)
    pfam16124
    Location:832
    RecQ_Zn_bind; RecQ zinc-binding
  4. XM_039085676.2XP_038941604.1  ATP-dependent DNA helicase Q5 isoform X4

    Conserved Domains (1) summary
    COG0514
    Location:15414
    RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

RNA

  1. XR_005489766.2 RNA Sequence