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Nkiras2 NFKB inhibitor interacting Ras-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287707, updated on 2-Nov-2024

Summary

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Official Symbol
Nkiras2provided by RGD
Official Full Name
NFKB inhibitor interacting Ras-like 2provided by RGD
Primary source
RGD:1307363
See related
EnsemblRapid:ENSRNOG00000018095 AllianceGenome:RGD:1307363
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activating protein binding activity. Predicted to be involved in Ral protein signal transduction. Predicted to act upstream of or within several processes, including lung alveolus development; regulation of signal transduction; and surfactant homeostasis. Predicted to be located in cytoplasm. Orthologous to human NKIRAS2 (NFKB inhibitor interacting Ras like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 123.8), Muscle (RPKM 109.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nkiras2 in Genome Data Viewer
Location:
10q31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86055029..86062398)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85554704..85562072)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88536564..88540739)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene chromosome 10 C17orf113 homolog pseudogene Neighboring gene zinc finger protein 385C Neighboring gene uncharacterized LOC120095293

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activating protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ral protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Ral protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung alveolus development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NF-kappa-B inhibitor-interacting Ras-like protein 2
Names
NFKB inhibitor interacting Ras-like protein 2
NP_001099309.1
XP_006247336.1
XP_038941539.1
XP_063124805.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105839.1 → NP_001099309.1  NF-kappa-B inhibitor-interacting Ras-like protein 2

    See identical proteins and their annotated locations for NP_001099309.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HJ49, D3ZCK2
    Related
    ENSRNOP00000024543.4, ENSRNOT00000024543.7
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86055029..86062398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085611.2 → XP_038941539.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HJ49, D3ZCK2
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_063268735.1 → XP_063124805.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HJ49, D3ZCK2

  3. XM_006247274.5 → XP_006247336.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006247336.1

    UniProtKB/TrEMBL
    A6HJ49, D3ZCK2
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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