Rpain RPA interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rpainprovided by RGD
Official Full Name: RPA interacting proteinprovided by RGD
Primary source: RGD:1308492
See related: EnsemblRapid:ENSRNOG00000006913 AllianceGenome:RGD:1308492
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308492
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within response to UV. Predicted to be located in PML body; cytoplasm; and fibrillar center. Predicted to be active in nucleus. Orthologous to human RPAIN (RPA interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 91.3), Testes (RPKM 76.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (56190975..56198490)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (55692410..55699910)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (57606287..57613834)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to UV	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RPA-interacting protein

Names: RAP interaction protein alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033060.2 → NP_001028232.2 RPA-interacting protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q4G2Y1

UniProtKB/TrEMBL

A0A8I6ASS9, A6HGA9

Related

ENSRNOP00000097917.2, ENSRNOT00000101989.2

Conserved Domains (3) summary

pfam14766
Location:8 → 46

RPA_interact_N; Replication protein A interacting N-terminal

pfam14767
Location:59 → 127

RPA_interact_M; Replication protein A interacting middle

pfam14768
Location:137 → 217

RPA_interact_C; Replication protein A interacting C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

56190975..56198490

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268664.1 → XP_063124734.1 RPA-interacting protein isoform X1
XM_039085489.2 → XP_038941417.1 RPA-interacting protein isoform X2

Conserved Domains (2) summary

pfam14766
Location:8 → 44

RPA_interact_N; Replication protein A interacting N-terminal

pfam14768
Location:43 → 118

RPA_interact_C; Replication protein A interacting C-terminal