U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tnfsf13 TNF superfamily member 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287437, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Tnfsf13provided by RGD
Official Full Name
TNF superfamily member 13provided by RGD
Primary source
RGD:1305871
See related
EnsemblRapid:ENSRNOG00000014171 AllianceGenome:RGD:1305871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
April; Tnlg7b
Summary
Predicted to enable receptor ligand activity. Predicted to be involved in positive regulation of B cell proliferation and positive regulation of isotype switching to IgA isotypes. Predicted to act upstream of or within immunoglobulin mediated immune response; positive regulation of cell population proliferation; and positive regulation of germinal center formation. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma. Orthologous to human TNFSF13 (TNF superfamily member 13). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 100.1), Kidney (RPKM 97.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tnfsf13 in Genome Data Viewer
Location:
10q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54898805..54901815, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54400054..54403723, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56286964..56290680, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene eukaryotic translation initiation factor 4A1 like Neighboring gene SUMO specific peptidase 3 Neighboring gene TNF superfamily member 12 Neighboring gene ribosomal protein L13, pseudogene 19

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. APRIL/BLyS deficient rats prevent donor specific antibody (DSA) production and cell proliferation in rodent kidney transplant model. Bath NM, et al. PLoS One, 2022. PMID 36227902, Free PMC Article
  2. APRIL promotes proliferation, secretion and invasion of fibroblast-like synoviocyte from rats with adjuvant induced arthritis. Chang Y, et al. Mol Immunol, 2015 Mar. PMID 25466610
  3. APRIL-deficient mice have normal immune system development. Varfolomeev E, et al. Mol Cell Biol, 2004 Feb. PMID 14729948, Free PMC Article
  4. APRIL promotes B-1 cell-associated neoplasm. Planelles L, et al. Cancer Cell, 2004 Oct. PMID 15488762
  5. Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development. Alexaki VI, et al. J Immunol, 2009 Nov 1. PMID 19828625

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. APRIL/BLyS deficient rats prevent donor specific antibody (DSA) production and cell proliferation in rodent kidney transplant model.
    Title: APRIL/BLyS deficient rats prevent donor specific antibody (DSA) production and cell proliferation in rodent kidney transplant model.
  2. APRIL may act as an important mediator for facilitating the function of fibroblast-like synoviocyte.
    Title: APRIL promotes proliferation, secretion and invasion of fibroblast-like synoviocyte from rats with adjuvant induced arthritis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC95053

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of germinal center formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of germinal center formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of isotype switching to IgA isotypes IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of isotype switching to IgA isotypes ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tumor necrosis factor ligand superfamily member 13
Names
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor ligand 7b
tumor necrosis factor superfamily member 13

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009623.2 → NP_001009623.1  tumor necrosis factor ligand superfamily member 13

    See identical proteins and their annotated locations for NP_001009623.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8J8XC20, A6HFT3, E9PSM9, Q5PQL1
    Related
    ENSRNOP00000053740.4, ENSRNOT00000056903.5
    Conserved Domains (1) summary
    cd00184
    Location:108 → 238
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54898805..54901815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268640.1 → XP_063124710.1  tumor necrosis factor ligand superfamily member 13 isoform X8

    UniProtKB/TrEMBL
    A0A0G2K4Q8

  2. XM_039085456.2 → XP_038941384.1  tumor necrosis factor ligand superfamily member 13 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K4Q8
    Conserved Domains (1) summary
    cd00184
    Location:98 → 222
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

  3. XM_063268638.1 → XP_063124708.1  tumor necrosis factor ligand superfamily member 13 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K4Q8

  4. XM_008767802.4 → XP_008766024.1  tumor necrosis factor ligand superfamily member 13 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K4Q8
    Related
    ENSRNOP00000073136.3, ENSRNOT00000090762.3
    Conserved Domains (1) summary
    cd00184
    Location:109 → 223
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

  5. XM_039085458.2 → XP_038941386.1  tumor necrosis factor ligand superfamily member 13 isoform X6

    UniProtKB/TrEMBL
    A0A8J8XC20, A6HFT3
    Conserved Domains (1) summary
    cl00147
    Location:108 → 207
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

  6. XM_039085452.2 → XP_038941380.1  tumor necrosis factor ligand superfamily member 13 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XC20, A6HFT3
    Conserved Domains (1) summary
    cd00184
    Location:108 → 238
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

  7. XM_063268639.1 → XP_063124709.1  tumor necrosis factor ligand superfamily member 13 isoform X5

    UniProtKB/TrEMBL
    A0A8J8XC20, A6HFT3

  8. XM_008767796.4 → XP_008766018.1  tumor necrosis factor ligand superfamily member 13 isoform X1

    See identical proteins and their annotated locations for XP_008766018.1

    UniProtKB/TrEMBL
    A0A8J8XC20, A6HFT3
    Related
    ENSRNOP00000106612.1, ENSRNOT00000167300.1
    Conserved Domains (1) summary
    cd00184
    Location:108 → 239
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.